N-(3,5-bis(trifluoromethyl)phenyl)-2-(piperazin-1-yl)acetamide hydrochloride

Base Information

Chemical Name:N-(3,5-bis(trifluoromethyl)phenyl)-2-(piperazin-1-yl)acetamide hydrochloride
CAS No.:1269773-40-1
Molecular Formula:C₁₄H₁₅F₆N₃O*ClH
Molecular Weight:391.744
Hs Code.:

Synonyms:N-(3,5-bis(trifluoromethyl)phenyl)-2-(piperazin-1-yl)acetamide hydrochloride

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Chemical Property of N-(3,5-bis(trifluoromethyl)phenyl)-2-(piperazin-1-yl)acetamide hydrochloride

Chemical Property:

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Technology Process of N-(3,5-bis(trifluoromethyl)phenyl)-2-(piperazin-1-yl)acetamide hydrochloride

There total 3 articles about N-(3,5-bis(trifluoromethyl)phenyl)-2-(piperazin-1-yl)acetamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1269773-69-4
tert-butyl 4-(2-(3,5-bis(trifluoromethyl)phenylamino)-2-oxoethyl)piperazine-1-carboxylate

: 1269773-40-1
N-(3,5-bis(trifluoromethyl)phenyl)-2-(piperazin-1-yl)acetamide hydrochloride

Guidance literature:: With hydrogenchloride; In diethyl ether; dichloromethane; at 20 ℃;

Reference yield:

: 328-74-5
3,5-Bis-(trifluoromethyl)aniline

: 1269773-40-1
N-(3,5-bis(trifluoromethyl)phenyl)-2-(piperazin-1-yl)acetamide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 3 h / 0 - 20 °C

2: potassium carbonate / acetonitrile / 6 h / Reflux

3: hydrogenchloride; water / methanol / 6 h / 60 °C

With hydrogenchloride; water; potassium carbonate; triethylamine; In methanol; dichloromethane; acetonitrile;
DOI:10.5012/bkcs.2012.33.8.2597

Reference yield:

: 99468-72-1
N-[3,5-bis(trifluoromethyl)phenyl]-2-bromoacetamide

: 1269773-40-1
N-(3,5-bis(trifluoromethyl)phenyl)-2-(piperazin-1-yl)acetamide hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 6 h / Reflux

2: hydrogenchloride; water / methanol / 6 h / 60 °C

With hydrogenchloride; water; potassium carbonate; In methanol; acetonitrile;
DOI:10.5012/bkcs.2012.33.8.2597