Thiourea, N-(6-methoxy-2-benzothiazolyl)-N'-phenyl-

Base Information

• Chemical Name: Thiourea, N-(6-methoxy-2-benzothiazolyl)-N'-phenyl-
• CAS No.: 32294-42-1
• Molecular Formula: C15H13N3OS2
• Molecular Weight: 315.42
• Hs Code.: 2934200090
• Mol file: 32294-42-1.mol

Synonyms:1-(6-methoxybenzo[d]thiazol-2-yl)-3-phenylthiourea;

Chemical Property of Thiourea, N-(6-methoxy-2-benzothiazolyl)-N'-phenyl-

Chemical Property:

• PSA: 113.55000
• LogP: 4.40730

Purity/Quality:

≥99% ^*data from raw suppliers

1-(6-methoxybenzo[d]thiazol-2-yl)-3-phenylthiourea 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Thiourea, N-(6-methoxy-2-benzothiazolyl)-N'-phenyl-

There total 4 articles about Thiourea, N-(6-methoxy-2-benzothiazolyl)-N'-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

aniline (62-53-3) + N-(6-methoxybenzo[d]thiazol-2-yl)-1H-imidazole-1-carbothioamide (756476-97-8) → N-phenyl-N'-(6-methoxy)benzothiazolylthiocarbamide (32294-42-1)

Guidance literature:

In N,N-dimethyl-formamide; at 60 ℃;

DOI:10.2174/1573406413666170109142725

Reference yield: 15.0%

6-methoxybenzothiazol-2-ylamine (1747-60-0) + phenyl isothiocyanate (103-72-0) → N-phenyl-N'-(6-methoxy)benzothiazolylthiocarbamide (32294-42-1)

Guidance literature:

With iodine; potassium carbonate; In chloroform; at 60 ℃; for 12h;

DOI:10.1021/acs.joc.0c00421

Reference yield:

6-methoxybenzothiazol-2-ylamine (1747-60-0) + aniline (62-53-3) + 1,1'-Thiocarbonyldiimidazole (6160-65-2) → N-phenyl-N'-(6-methoxy)benzothiazolylthiocarbamide (32294-42-1)

Guidance literature:

6-methoxybenzothiazol-2-ylamine; 1,1'-Thiocarbonyldiimidazole; In acetonitrile; at 20 ℃;

aniline; In N,N-dimethyl-formamide; at 100 ℃;

DOI:10.1016/j.bmcl.2006.05.099

upstream raw materials:

6-methoxybenzothiazol-2-ylamine

phenyl isothiocyanate

aniline

1,1'-Thiocarbonyldiimidazole

Downstream raw materials:

N-isopropyl-N'-(6-methoxy-benzothiazol-2-yl)-N''-phenyl-guanidine

{Mn(C₆H₅NC(S)NH(C₇H₃NSOCH₃))2(H₂O)2}

Refernces

• 1、 Benek, Ondrej,Hroch, Lukas,Aitken, Laura,Dolezal, Rafael,Hughes, Rebecca,Guest, Patrick,Benkova, Marketa,Soukup, Ondrej,Musil, Karel,Kuca, Kamil,Smith, Terry K.,Gunn-Moore, Frank,Musilek, Kamil. "6-Benzothiazolyl ureas, thioureas and guanidines are potent inhibitors of ABAD/17-HSD10 and potential drugs for Alzheimer's disease treatment: Design, synthesis and in vitro evaluation". . p. 345 - 358. Retrieved 2017/06/20.
• 2、 Nakrani,Rathod,Shah. "Manganese(II) complexes of N-phenyl-N'-(6-substituted)benzothiazolylthiocarbamide". . p. 517 - 518. Retrieved 2007/10/02.