Benzenemethanol, a-1-propynyl-

Base Information

• Chemical Name: Benzenemethanol, a-1-propynyl-
• CAS No.: 32398-66-6
• Molecular Formula: C10H10O
• Molecular Weight: 146.189
• Mol file: 32398-66-6.mol

Synonyms:4-hydroxy-4-phenyl-2-butyne;rac-1-phenylbut-2-yn-1-ol;1-hydroxy-1-phenylbut-2-yne;phenyl-1 butyne-2 ol-1;1-Phenyl-2-butyn-1-ol;(+/-)-1-phenyl-2-butynol;

Chemical Property of Benzenemethanol, a-1-propynyl-

Chemical Property:

• Melting Point: 37 °C
• Boiling Point: 110 °C(Press: 0.8 Torr)
• PSA: 20.23000
• Density: 1.068±0.06 g/cm3(Predicted)
• LogP: 1.74330

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenemethanol, a-1-propynyl-

There total 25 articles about Benzenemethanol, a-1-propynyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-propynylmagnesium bromide (16466-97-0,13254-27-8) + benzaldehyde (100-52-7) → 1-phenylbut-2-yn-1-ol (32398-66-6)

Guidance literature:

In tetrahydrofuran;

DOI:10.1002/anie.201106381

Reference yield: 94.0%

1-bromo-1-propene (590-14-7) + benzaldehyde (100-52-7) → 1-phenylbut-2-yn-1-ol (32398-66-6)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; at -78 ℃;

DOI:10.15227/orgsyn.076.0214

Reference yield: 91.0%

propargyl magnesium bromide (18295-60-8) + benzaldehyde (100-52-7) → 1-phenylbut-2-yn-1-ol (32398-66-6)

Guidance literature:

In tetrahydrofuran; at -78 - 20 ℃; for 1h;

DOI:10.1021/ja0528580

upstream raw materials:

1-propynylmagnesium bromide

benzaldehyde

1-propynyl lithium

propargyl magnesium bromide

Downstream raw materials:

(2E)-1-phenylbut-2-en-1-ol

1-(1-methoxybut-2-ynyl)benzene

(Z)-1-phenyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)but-2-en-1-ol

(S)-1-Phenyl-but-2-yn-1-ol