4-methoxy-3,5-dimethylbenzenamine

Base Information

• Chemical Name: 4-methoxy-3,5-dimethylbenzenamine
• CAS No.: 32407-11-7
• Molecular Formula: C7H7Cl2NO
• Molecular Weight: 192.045
• Mol file: 32407-11-7.mol

Synonyms:3,5-dichloro-4-methoxy-aniline;3,5-dichloroanisidine;3.5-Dichlor-p-anisidin;3,5-Dichlor-4-methoxy-anilin;Benzenamine,3,5-dichloro-4-methoxy;4-Amino-2,6-dichloroanisole;

Chemical Property of 4-methoxy-3,5-dimethylbenzenamine

Chemical Property:

• Melting Point: 80-80.5 °C
• Boiling Point: 128 °C(Press: 4 Torr)
• PKA: 3.08±0.10(Predicted)
• PSA: 35.25000
• Density: 1.375±0.06 g/cm3(Predicted)
• LogP: 3.16540

Purity/Quality:

99% ^*data from raw suppliers

3,5-dichloro-4-methoxyaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-methoxy-3,5-dimethylbenzenamine

There total 5 articles about 4-methoxy-3,5-dimethylbenzenamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2,6-dichloro-4-nitro-anisole (17742-69-7) → 3,5-dichloro-4-methoxyaniline (32407-11-7)

Guidance literature:

With tin(ll) chloride; In hydrogenchloride; ethanol; at 60 ℃; for 1h;

DOI:10.1007/s002440010298

Reference yield:

tin(II)chloride dihydrate + 2,6-dichloro-4-nitro-anisole (17742-69-7) → 3,5-dichloro-4-methoxyaniline (32407-11-7)

Guidance literature:

With sodium hydroxide; In ethanol;

Reference yield:

2,6-dichloro-4-nitrophenol (618-80-4) → 3,5-dichloro-4-methoxyaniline (32407-11-7)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃

2: H₂ / PtO₂

With hydrogen; potassium carbonate; platinum(IV) oxide;

DOI:10.1021/jo01041a056

upstream raw materials:

2,6-dichloro-4-nitro-anisole

2,6-dichloro-4-nitrophenol

3,5-dichloro-4-fluoro-nitrobenzene

Downstream raw materials:

3',5'-dichloro-2-hydroxy-4'-methoxybenzanilide

Refernces

• 1、 -. "THYROID HORMONE RECEPTOR AGONISTS AND USES THEREOF". Paragraph 00392; 00393; 00400; 00401. . Retrieved 2020/01/08.
• 2、 -. "NOVEL FLUORESCENT DYES AND USES THEREOF". Page/Page column 32-33. . Retrieved 2011/02/24.