618-80-4Relevant articles and documents
Synthesis method of 2, 6-dichloro-4-aminophenol
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Paragraph 0023; 0031; 0033; 0035; 0037, (2021/06/12)
The invention discloses a synthesis method of 2, 6-dichloro-4-aminophenol, and belongs to the field of preparation of pesticide, medicine and dye intermediates, 2, 6-dichloro-4-aminophenol is obtained by adopting paranitroaniline as a raw material through the steps of chlorination, diazonium hydrolysis, hydrogenation and the like, methanol is adopted as a solvent for chlorination, filtrate can be repeatedly used, and the use of a large amount of acid water is reduced; toluene is selected as a solvent in diazotization, diazonium liquid is directly layered after being hydrolyzed, an organic layer is separated out, water vapor distillation is not needed, and the distillation risk and energy consumption are reduced; toluene is selected as a hydrogenation solvent, and an organic layer separated after the diazonium liquid is hydrolyzed is directly hydrogenated, so that the process flow is simplified.
Synthesis method of chlorfluazuron key intermediate 2, 6-dichloro-4-nitrophenol
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Paragraph 0074-0119, (2020/08/02)
The invention provides a synthesis method of a chlorfluazuron key intermediate 2, 6-dichloro-4-nitrophenol. According to the method, p-nitrobenzene is used as a raw material to prepare 2, 6-dichloro-4-nitrophenol in a chlorine and hydrochloric acid system so that the product yield is high, the production of byproducts can be inhibited by hydrochloric acid, the product purity is high, the hydrochloric acid mother liquor can be recycled, and the resource utilization of three wastes is realized; when the method is used for synthesizing the 2, 6-dichloro-4-aminophenol, the high-purity 2, 6-dichloro-4-aminophenol can be prepared due to the fact that the purity of the intermediate 2, 6-dichloro-4-nitrophenol is high, and high industrial application value is achieved.
Synthesis method of chlorfluazuron and application of chlorfluazuron in insecticide preparation
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Paragraph 0037; 0039; 0040, (2017/07/21)
The invention belongs to the technical field of pesticide preparations, particularly relates to a synthesis method of chlorfluazuron and further discloses an application of chlorfluazuron in insecticide preparation. According to the synthesis method of chlorfluazuron, chlorfluazuron is prepared from 2,3-dichloro-5-(trifluoromethyl)pyridine, 2,6-dichloro-4-aminophenol and 2,6-difluorobenzoyl isocyanate as synthetic raw materials and N,N-dimethylacetamide as a reaction solvent on the basis of a conventional synthesis route in the prior art; under the action of a ZSM molecular sieve based catalyst, not only can synthesis of chlorfluazuron be realized, but also a reaction can be performed with the same reaction solvent, so that the problem of complicated process caused by the fact that solvents are required to be recovered step by step during two-step synthesis of chlorfluazuron in the prior art is solved; compared with the technology in the prior art, the synthesis method of chlorfluazuron has the advantages that the synthesis yield of products is further increased and product content is higher.