Technology Process of 4-Benzyl-3-[5-chloro-2-(propan-2-yl)pent-4-enoyl]-1,3-oxazolidin-2-one
There total 2 articles about 4-Benzyl-3-[5-chloro-2-(propan-2-yl)pent-4-enoyl]-1,3-oxazolidin-2-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(S)-4-benzyl-3-(3-methylbutanoyl)oxazolidin-2-one;
With
lithium hexamethyldisilazane;
In
tetrahydrofuran;
at -78 ℃;
for 2.08333h;
1,3-chloroiodopropene;
In
tetrahydrofuran;
at -78 - 0 ℃;
for 20h;
With
water; ammonium chloride;
In
tetrahydrofuran;
- Guidance literature:
-
(S)-4-benzyl-3-(3-methylbutanoyl)oxazolidin-2-one;
With
lithium hexamethyldisilazane;
In
tetrahydrofuran;
at -78 ℃;
for 1h;
Li-compound was added over a period of 65 min;
1,3-chloroiodopropene;
In
tetrahydrofuran;
at 0 ℃;
for 20h;
- Guidance literature:
-
C18H22ClNO3;
With
lithium hydroxide; water; dihydrogen peroxide;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 5h;
With
sodium sulfite;
In
tetrahydrofuran; water;
at 0 ℃;
for 0.5h;
With
hydrogenchloride; sodium carbonate;
more than 3 stages;
