Hydrazinecarboxamide, 2-[1-(4-fluorophenyl)ethylidene]-

Base Information

• Chemical Name: Hydrazinecarboxamide, 2-[1-(4-fluorophenyl)ethylidene]-
• CAS No.: 326-33-0
• Molecular Formula: C9H10FN3O
• Molecular Weight: 195.196
• Mol file: 326-33-0.mol

Synonyms:

Chemical Property of Hydrazinecarboxamide, 2-[1-(4-fluorophenyl)ethylidene]-

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Hydrazinecarboxamide, 2-[1-(4-fluorophenyl)ethylidene]-

There total 3 articles about Hydrazinecarboxamide, 2-[1-(4-fluorophenyl)ethylidene]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

semicarbazide hydrochloride (563-41-7) + 1-(4-fluorophenyl)ethanone (403-42-9) → 4-fluoroacetophenone semicarbazone (326-33-0)

Guidance literature:

With sodium acetate; In methanol; water;

DOI:10.1016/j.bmcl.2008.08.058

Reference yield:

1-(4-fluorophenyl)ethanone (403-42-9) + hydrazine carboxamide (4426-72-6,51433-48-8,57-56-7) → 4-fluoroacetophenone semicarbazone (326-33-0)

Guidance literature:

In ethanol; for 2h; Reflux;

Reference yield:

→ 4-fluoroacetophenone semicarbazone (326-33-0)

Guidance literature:

upstream raw materials:

semicarbazide hydrochloride

1-(4-fluorophenyl)ethanone

hydrazine carboxamide

Downstream raw materials:

5-[[3-(4-fluorophenyl)-1H-pyrazol-4-yl]methylene]-2-imino-3-(2-thiazolyl)-4-thiazolidinone

1-benzyl-3-(4-fluorophenyl)-1H-pyrazole-4-carbaldehyde

3-(4-fluorophenyl)-1-methyl-1H-pyrazole-4-carbaldehyde

C₁₁H₉FN₂O₄S

Refernces

• 1、 Wang, Wang,Xiong, Liangliang,Li, Yutong,Song, Zhuorui,Sun, Dejuan,Li, Hua,Chen, Lixia. "Synthesis of lathyrane diterpenoid nitrogen-containing heterocyclic derivatives and evaluation of their anti-inflammatory activities". . . Retrieved 2022/01/24.
• 2、 Liang, Zhaochang,Huang, Yuping,Wang, Shiben,Deng, Xianqing. "Synthesis and biological evaluation of some pyrazole derivatives, containing (Thio) semicarbazide, as dual anti-inflammatory antimicrobial agents". . p. 1020 - 1030. Retrieved 2019/10/28.