Semicarbazide hydrochloride

Base Information

• Chemical Name: Semicarbazide hydrochloride
• CAS No.: 563-41-7
• Molecular Formula: CH5N3O^.HCl
• Molecular Weight: 111.531
• Hs Code.: 2928 00 90
• European Community (EC) Number: 209-247-0
• NSC Number: 4732
• UN Number: 2811
• UNII: 34854VG84B
• DSSTox Substance ID: DTXSID4020244
• Wikidata: Q27156046
• ChEMBL ID: CHEMBL1256355
• Mol file: 563-41-7.mol

Synonyms:Hydrazinecarboxamide,monohydrochloride (9CI);Semicarbazide, monohydrochloride (8CI);Aminoureahydrochloride;Hydrazinecarboxamide, hydrochloride;Semicarbazide chloride;

Chemical Property of Semicarbazide hydrochloride

Chemical Property:

• Appearance/Colour: White solid
• Vapor Pressure: 0.0407mmHg at 25°C
• Melting Point: 175-177 °C (dec.)(lit.)
• Refractive Index: 1.4480 (estimate)
• Boiling Point: 235.3 °C at 760 mmHg
• Flash Point: 96.1 °C
• PSA: 81.14000
• Density: 1.286g/cm3
• LogP: 1.12190
• Storage Temp.: -20°C Freezer, Under Inert Atmosphere
• Solubility.: H2O: 0.1 g/mL at 20 °C, clear, colorless
• Water Solubility.: 100 g/L (15 ºC)
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 111.0199395
• Heavy Atom Count: 6
• Complexity: 42.2
• Transport DOT Label: Poison

Purity/Quality:

99% ^*data from raw suppliers

Semicarbazide hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn, T
• Hazard Codes: Xn,T
• Statements: 22-40-36/38-25-45-23/24/25
• Safety Statements: 24/25-22-45-53

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Nitrogen Compounds -> Other Nitrogen Compounds
• Canonical SMILES: C(=O)(N)NN.Cl
• Uses: Inhibitor of enzyme. Hypotensive Semicarbazide hydrochloride is used as urease substrate and MAO inhibitor. Derivatizing agent for carbonyl compounds as their semicarbazones which produces crystalline compounds with characteristic melting points. Also used in heterocyclic synthesis. Semicarbazone formation has been used to separate carbonyl compounds from mixtures by adsorption onto silica gel from a hydrocarbon solution. Regeneration is by hydrolysis with oxalic acid.

Technology Process of Semicarbazide hydrochloride

There total 14 articles about Semicarbazide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

hydrogenchloride (7647-01-0,15364-23-5) + 2,6-dimethyl-6-semicarbazido-hept-2-en-4-one semicarbazone → phorone (504-20-1) + semicarbazide hydrochloride (563-41-7)

Guidance literature:

Reference yield:

nitrofurazone (59-87-0) → semicarbazide hydrochloride (563-41-7)

Guidance literature:

With hydrogenchloride; In water; at 25 ℃; for 12h;

DOI:10.1021/acs.jafc.7b01050

Reference yield:

potassium cyanate (590-28-3) + hydrazinium sulfate (10034-93-2) → semicarbazide hydrochloride (563-41-7)

Guidance literature:

With hydrogenchloride; sodium carbonate; acetone; In water; byproducts: hydrazodicarbonamide; addn. of aq. KOCN to warm (50-60°C) aq. soln. of hydrazine sulfate and Na2CO3; mixt. allowed to stand for 1 d; filtration of hydrazodicarbonamide; addn. of acetone; acetone semicarbazone extd. with ethanol and heated with concd. HCl;

upstream raw materials:

benzaldehyde semicarbazone

hydrogenchloride

thiazolidine-2,4-dione-2-semicarbazone

2-carbamothioyl-N-phenylhydrazine carboxamide

Downstream raw materials:

4-methylbenzaldehyde semicarbazone

(E)-2-(2-methylbenzylidene)hydrazine-1-carboxamide

phenylacetaldehyde semicarbazone

3-methyl-butan-2-one semicarbazone

Refernces

Formation of reagent-selective products from 2-(4,5-dihydrothi- azol-2-ylthio)-1-arylethanone with different nucleophiles

10.1080/17415993.2010.533772

The study investigates the reactions of 2-(4,5-dihydrothiazol-2-ylthio)-1-arylethanone with various nucleophiles, including semicarbazide hydrochloride, hydroxylamine hydrochloride, hydrazine, ethylenediamine, and aminoethanol, to form a range of products selective to the reagents used. The purpose of these reactions is to synthesize heterocyclic compounds containing selenium and sulfur, which are of interest due to their potential applications in the preparation of alkynes and their pharmacological properties, such as antifungal and antibacterial activities. The study explores the formation of different products with different nucleophiles, highlighting the selective nature of the reactions and the resulting compounds' structures, which were confirmed through techniques like single-crystal X-ray analysis.

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