5-(Chloromethyl)-2-methoxy-1,3-dimethylbenzene

Base Information

• Chemical Name: 5-(Chloromethyl)-2-methoxy-1,3-dimethylbenzene
• CAS No.: 32692-27-6
• Molecular Formula: C10H13ClO
• Molecular Weight: 184.666
• DSSTox Substance ID: DTXSID301291849
• Nikkaji Number: J747.822D
• Mol file: 32692-27-6.mol

Synonyms:5-(CHLOROMETHYL)-2-METHOXY-1,3-DIMETHYLBENZENE;32692-27-6;SCHEMBL4597547;LPXOIKVSOLVHFH-UHFFFAOYSA-N;DTXSID301291849;2,6-Dimethyl-4-(chloromethyl)anisole;3,5-Dimethyl-4-methoxybenzyl chloride;CS-0280089;5-Chloromethyl-2-methoxy-1,3-dimethylbenzene;5-chloromethyl-2-methoxy-1,3-dimethyl-benzene;EN300-1982275

Chemical Property of 5-(Chloromethyl)-2-methoxy-1,3-dimethylbenzene

Chemical Property:

• PSA: 9.23000
• LogP: 3.05080
• XLogP3: 3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 184.0654927
• Heavy Atom Count: 12
• Complexity: 126

Purity/Quality:

99% ^*data from raw suppliers

5-(chloromethyl)-2-methoxy-1,3-dimethylbenzene 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=CC(=C1OC)C)CCl

Technology Process of 5-(Chloromethyl)-2-methoxy-1,3-dimethylbenzene

There total 5 articles about 5-(Chloromethyl)-2-methoxy-1,3-dimethylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2-methoxy-1,3-dimethylbenzene (1004-66-6) → 4-chloromethyl-2,6-dimethyl-anisole (32692-27-6)

Guidance literature:

With hydrogenchloride; acetic acid; at 60 ℃; for 4h;

Reference yield:

2-methoxy-1,3-dimethylbenzene (1004-66-6) → 4-chloromethyl-2,6-dimethyl-anisole (32692-27-6)

Guidance literature:

With hydrogenchloride; formaldehyd; In acetic acid;

Reference yield:

2.6-dimethylphenol (576-26-1,25134-01-4) → 4-chloromethyl-2,6-dimethyl-anisole (32692-27-6)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaOH / Heating

2: aq. HCl, HCl / acetic acid

With hydrogenchloride; sodium hydroxide; In acetic acid;

upstream raw materials:

(4-methoxy-3,5-dimethylphenyl)methanol

1,3,5-Trioxan

2-methoxy-1,3-dimethylbenzene

formaldehyd

Downstream raw materials:

α-Acetamido-α-<4-methoxy-3,5-dimethylbenzyl>-malonsaeurediethylester

2-Acetamino-3-<4-methoxy-3,5-dimethyl-phenyl>-2-cyan-propionsaeure-ethylester

4,4'-dimethoxy-3,5,3',5'-tetramethyl-bibenzyl

(4-methoxy-3,5-dimethyl-benzyl)-triphenyl-phosphonium chloride