1,5-Diphenyl-1H-pyrazole-4-acetic acid

Base Information

• Chemical Name: 1,5-Diphenyl-1H-pyrazole-4-acetic acid
• CAS No.: 32702-05-9
• Molecular Formula: C17H14N2O2
• Molecular Weight: 278.30500
• Mol file: 32702-05-9.mol

Synonyms:6-Isopentylamino-2-methyl-heptan;Ludoctal;Octometine;Neo-octon;Octamylamine;Octinum D;Oktin D;Octin D;Octisamyl;

Chemical Property of 1,5-Diphenyl-1H-pyrazole-4-acetic acid

Chemical Property:

• Vapor Pressure: 5.79E-11mmHg at 25°C
• Boiling Point: 503.6oC at 760 mmHg
• Flash Point: 258.4oC
• PSA: 55.12000
• Density: 1.2g/cm3
• LogP: 3.16640

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,5-Diphenyl-1H-pyrazole-4-acetic acid

There total 5 articles about 1,5-Diphenyl-1H-pyrazole-4-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-(1,5-diphenyl-1H-pyrazol-4-yl)acetonitrile (153863-50-4) → (1,5-diphenyl-1H-pyrazol-4-yl)-acetic acid (32702-05-9)

Guidance literature:

With potassium hydroxide; In ethanol; for 10h; Heating;

DOI:10.1002/jhet.5570300427

Reference yield:

1,5-diphenyl-1H-pyrazole-4-carboxylic acid ethyl ester (53561-07-2) → (1,5-diphenyl-1H-pyrazol-4-yl)-acetic acid (32702-05-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 52 percent / LiAlH₄ / diethyl ether / 7 h / Heating

2: 48percent hydrobromic acid, acetic acid / 15 h / Heating

3: dimethylsulfoxide / 0.17 h / Ambient temperature

4: 91 percent / aq. KOH / ethanol / 10 h / Heating

With potassium hydroxide; lithium aluminium tetrahydride; hydrogen bromide; acetic acid; In diethyl ether; ethanol; dimethyl sulfoxide;

DOI:10.1002/jhet.5570300427

Reference yield:

(1,5-Diphenyl-1H-pyrazol-4-yl)-methanol (153863-42-4) → (1,5-diphenyl-1H-pyrazol-4-yl)-acetic acid (32702-05-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 48percent hydrobromic acid, acetic acid / 15 h / Heating

2: dimethylsulfoxide / 0.17 h / Ambient temperature

3: 91 percent / aq. KOH / ethanol / 10 h / Heating

With potassium hydroxide; hydrogen bromide; acetic acid; In ethanol; dimethyl sulfoxide;

DOI:10.1002/jhet.5570300427

upstream raw materials:

2-(1,5-diphenyl-1H-pyrazol-4-yl)acetonitrile

1,5-diphenyl-1H-pyrazole-4-carboxylic acid ethyl ester

(1,5-Diphenyl-1H-pyrazol-4-yl)-methanol

4-Bromomethyl-1,5-diphenyl-1H-pyrazole

Downstream raw materials:

(5-p-chlorophenyl-1-phenyl-pyrazol-4-yl)-acetic acid

Refernces

• 1、 -. "Pyrazol-4-acetic acid compounds". . . Retrieved 2008/06/13.