2-chloro-4-methyl-6-phenylpyrimidine

Base Information

• Chemical Name: 2-chloro-4-methyl-6-phenylpyrimidine
• CAS No.: 32785-40-3
• Molecular Formula: C11H9ClN2
• Molecular Weight: 204.659
• Hs Code.: 2933599090
• Mol file: 32785-40-3.mol

Synonyms:2-chloro-4-methyl-6-phenyl-pyrimidine;Pyrimidine,2-chloro-4-methyl-6-phenyl;2-Chlor-4-methyl-6-phenyl-pyrimidin;2-chloro-4-phenyl-6-methylpyrimidine;

Chemical Property of 2-chloro-4-methyl-6-phenylpyrimidine

Chemical Property:

• Melting Point: 50-51 °C
• Boiling Point: 351.2±11.0 °C(Predicted)
• PKA: -0.66±0.30(Predicted)
• PSA: 25.78000
• Density: 1.208±0.06 g/cm3(Predicted)
• LogP: 3.10540
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

2-Chloro-4-methyl-6-phenylpyrimidine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-chloro-4-methyl-6-phenylpyrimidine

There total 6 articles about 2-chloro-4-methyl-6-phenylpyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

2,4-dichloro-6-methylpyrimidine (5424-21-5) + phenylboronic acid (98-80-6) → 2-chloro-4-phenyl-6-methylpyrimidine (32785-40-3)

Guidance literature:

2,4-dichloro-6-methylpyrimidine; phenylboronic acid; With sodium carbonate; In ethanol; toluene; for 0.166667h; Schlenk technique; Inert atmosphere;

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; toluene; for 48h; Reflux; Inert atmosphere; Schlenk technique;

DOI:10.1016/j.dyepig.2021.109622

Reference yield: 49.0%

methyl magnesium iodide (917-64-6) + 2,4-dichloro-6-phenyl-pyrimidine (26032-72-4) → 2-chloro-4-phenyl-6-methylpyrimidine (32785-40-3)

Guidance literature:

1,3-bis[(diphenylphosphino)propane]dichloronickel(II); In diethyl ether; at 0 ℃;

Reference yield:

phenylmagnesium bromide → 2-chloro-4-phenyl-6-methylpyrimidine (32785-40-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 82 percent / dichloro-1,3-bis(diphenylphosphinopropane)nickel(II) / diethyl ether / 0 °C

2: 84 percent / triethylamine / toluene / 5 h / Heating

3: 49 percent / dichloro-1,3-bis(diphenylphosphinopropane)nickel(II) / diethyl ether / 0 °C

With triethylamine; 1,3-bis[(diphenylphosphino)propane]dichloronickel(II); In diethyl ether; toluene;

upstream raw materials:

methyl magnesium iodide

2,4-dichloro-6-phenyl-pyrimidine

2,4-dichloro-5-fluoro-6-phenyl-1,6-dihydropyrimidine

6-phenyl-2,4,5-trichloro-1,6-dihydropyrimidine

Downstream raw materials:

4-methyl-6-phenylpyrimidine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 32785-40-3 2-chloro-4-methyl-6-phenylpyrimidine

Send

Send

Metric Ton KG G Pound L ML

Send

Send