METHYLMAGNESIUM IODIDE

Base Information

• Chemical Name: METHYLMAGNESIUM IODIDE
• CAS No.: 917-64-6
• Molecular Formula: CH3 I Mg
• Molecular Weight: 166.244
• Hs Code.: 29319090
• European Community (EC) Number: 213-031-1
• DSSTox Substance ID: DTXSID301015526
• Mol file: 917-64-6.mol

Synonyms:Methylmagnesiumiodide (6CI);Iodomethylmagnesium;methylmagnesium iodine;

Chemical Property of METHYLMAGNESIUM IODIDE

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 0.00000
• Density: g/cm³
• LogP: 1.46950
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 165.91299
• Heavy Atom Count: 3
• Complexity: 4.8

Purity/Quality:

98% ^*data from raw suppliers

MethylmagnesiumIodide(3.0MinDiethylether) ^*data from reagent suppliers

Safty Information:

• Hazard Codes: F+,C,F
• Statements: 12-14/15-22-34-66-67-19-11
• Safety Statements: 16-26-36/37/39-43-45-7/8

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: [CH3-].[Mg+2].[I-]
• Uses: Alkylating agent in organic synthesis, Grignardreagent. Methylmagnesium iodide solution can be used: To prepare cis-1,2-dialkylcyclopropanols by treating with titanium(IV) alkoxide and carboxylic esters. In stereospecific Ni catalyzed Kumada cross-coupling reactions of benzylic ethers. To prepare 2,4-disubstituted selenochromenes by reacting with 1-benzoselenopyrylium salts. In one of the key synthetic steps for the preparation of 7β-methyl-substituted 5-androstene derivatives from 3β-acetoxyandrost-5-en-17-one stereoselectively.

Technology Process of METHYLMAGNESIUM IODIDE

There total 19 articles about METHYLMAGNESIUM IODIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

→ methyl magnesium iodide (917-64-6)

Guidance literature:

Reference yield: 94.0%

methyl iodide (74-88-4) → methyl magnesium iodide (917-64-6)

Guidance literature:

With magnesium; In diethyl ether; at 25 ℃; under 5171.62 Torr; Inert atmosphere; Flow reactor;

DOI:10.3762/bjoc.16.115

Reference yield: 90.0%

→ methyl magnesium iodide (917-64-6) + 2,3-Dichloro-α-methylbenzyl alcohol (54798-91-3)

Guidance literature:

upstream raw materials:

TETRAHYDROPYRANE

methyl iodide

diethyl ether

dibutyl ether

Downstream raw materials:

1,1-dimethyl-1-silacyclohexane

6-methyl-2,3,4,5-tetrahydro-pyridine

3-cyclohexylidene-2-methyl-propene

Benzyldimethylphosphin

Refernces

• 1、 Drakopoulos, Antonios,Tzitzoglaki, Christina,Ma, Chulong,Freudenberger, Kathrin,Hoffmann, Anja,Hu, Yanmei,Gauglitz, Günter,Schmidtke, Michaela,Wang, Jun,Kolocouris, Antonios. "Affinity of Rimantadine Enantiomers against Influenza A/M2 Protein Revisited". . p. 145 - 150. Retrieved 2017.
• 2、 -. "Method for preparing 1, 1 and 1 -trifluoro -2 -methyl -2 - propanol". Paragraph 0038. . Retrieved 2021/12/07.
• 3、 Borovik, Andy S.,Dawson, David D.,Jarvo, Elizabeth R.,Oswald, Victoria F.. "Identification of the Active Catalyst for Nickel-Catalyzed Stereospecific Kumada Coupling Reactions of Ethers". supporting information. . Retrieved 2020/03/04.