1-Pyrrolidinecarboxylic acid, 3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-2-[(1R)-1-[[[(1,1-dimethylethyl)di phenylsilyl]oxy]methyl]-3-[(methylsulfonyl)oxy]propyl]-, phenylmethyl ester, (2R,3R)-

Base Information

Chemical Name:1-Pyrrolidinecarboxylic acid, 3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-2-[(1R)-1-[[[(1,1-dimethylethyl)di phenylsilyl]oxy]methyl]-3-[(methylsulfonyl)oxy]propyl]-, phenylmethyl ester, (2R,3R)-
CAS No.:328404-69-9
Molecular Formula:C49H61NO7SSi2
Molecular Weight:864.263
Hs Code.:

1-Pyrrolidinecarboxylic acid,
3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-2-[(1R)-1-[[[(1,1-dimethylethyl)di
phenylsilyl]oxy]methyl]-3-[(methylsulfonyl)oxy]propyl]-, phenylmethyl
ester, (2R,3R)-

Synonyms:

Suppliers and Price of 1-Pyrrolidinecarboxylic acid, 3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-2-[(1R)-1-[[[(1,1-dimethylethyl)di phenylsilyl]oxy]methyl]-3-[(methylsulfonyl)oxy]propyl]-, phenylmethyl ester, (2R,3R)-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Pyrrolidinecarboxylic acid, 3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-2-[(1R)-1-[[[(1,1-dimethylethyl)di phenylsilyl]oxy]methyl]-3-[(methylsulfonyl)oxy]propyl]-, phenylmethyl ester, (2R,3R)-

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 1-Pyrrolidinecarboxylic acid, 3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-2-[(1R)-1-[[[(1,1-dimethylethyl)di phenylsilyl]oxy]methyl]-3-[(methylsulfonyl)oxy]propyl]-, phenylmethyl ester, (2R,3R)-

There total 10 articles about 1-Pyrrolidinecarboxylic acid, 3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-2-[(1R)-1-[[[(1,1-dimethylethyl)di phenylsilyl]oxy]methyl]-3-[(methylsulfonyl)oxy]propyl]-, phenylmethyl ester, (2R,3R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 124-63-0
methanesulfonyl chloride

: 328404-68-8
3-(tert-butyl-diphenyl-silanyloxy)-2-[1-(tert-butyl-diphenyl-silanyloxymethyl)-3-hydroxy-propyl]-pyrrolidine-1-carboxylic acid benzyl ester

: 328404-69-9
3-(tert-butyl-diphenyl-silanyloxy)-2-[1-(tert-butyl-diphenyl-silanyloxymethyl)-3-methanesulfonyloxy-propyl]-pyrrolidine-1-carboxylic acid benzyl ester

Guidance literature:: With triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃;
DOI:10.1016/S0040-4039(00)01664-6

Reference yield:

: 95456-65-8
(1R,5R)-(-)-6-aza-6-benzyloxycarbonyl-2-oxabicyclo[3.3.0]octan-3-one

: 328404-69-9
3-(tert-butyl-diphenyl-silanyloxy)-2-[1-(tert-butyl-diphenyl-silanyloxymethyl)-3-methanesulfonyloxy-propyl]-pyrrolidine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: LiHMDS / tetrahydrofuran; hexamethylphosphoric acid triamide / 1 h / -78 °C

1.2: 57 percent / hexamethylphosphoric acid triamide; tetrahydrofuran / 1.5 h / -78 - -45 °C

2.1: 86 percent / NaBH₄ / aq. ethanol / 22 h / 20 °C

3.1: imidazole / dimethylformamide / 20 h / 20 °C

3.2: OsO₄; NaIO₄ / diethyl ether; H₂O / 36 h / 20 °C

3.3: 238.4 mg / NaBH₄ / aq. ethanol / 2 h / 0 °C

4.1: 88 percent / Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

With 1H-imidazole; sodium tetrahydroborate; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; dichloromethane; N,N-dimethyl-formamide; 3.2: Lemieux-Johnson oxidation;
DOI:10.1021/jo010753j

Reference yield:

: 328404-56-4
(R)-3-[(1-bezyloxy-carbonyl)-pyrrolidinyl]-α-diazoacetate

: 328404-69-9
3-(tert-butyl-diphenyl-silanyloxy)-2-[1-(tert-butyl-diphenyl-silanyloxymethyl)-3-methanesulfonyloxy-propyl]-pyrrolidine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 78 percent / Rh₂[(4R)-1-(3-(PhCH₂CH₂CO)-2-imidazolidinone-4-COOMe)] / 1,2-dichloro-ethane / 2 h / 60 °C

2.1: LiHMDS / tetrahydrofuran; hexamethylphosphoric acid triamide / 1 h / -78 °C

2.2: 57 percent / hexamethylphosphoric acid triamide; tetrahydrofuran / 1.5 h / -78 - -45 °C

3.1: 86 percent / NaBH₄ / aq. ethanol / 22 h / 20 °C

4.1: imidazole / dimethylformamide / 20 h / 20 °C

4.2: OsO₄; NaIO₄ / diethyl ether; H₂O / 36 h / 20 °C

4.3: 238.4 mg / NaBH₄ / aq. ethanol / 2 h / 0 °C

5.1: 88 percent / Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

With 1H-imidazole; sodium tetrahydroborate; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; 4.2: Lemieux-Johnson oxidation;
DOI:10.1021/jo010753j