2-Methyl-4-(pyridin-3-ylethynyl)thiazole

Base Information

Chemical Name:2-Methyl-4-(pyridin-3-ylethynyl)thiazole
CAS No.:329205-68-7
Molecular Formula:C₁₁H₈N₂S
Molecular Weight:200.264
Hs Code.:
UNII:XDA7P9K5S6
DSSTox Substance ID:DTXSID30430775
Nikkaji Number:J1.877.066K
Wikipedia:MTEP
Wikidata:Q13566097
Pharos Ligand ID:B6FFTUMB8RUT
ChEMBL ID:CHEMBL292065
Mol file:329205-68-7.mol

Synonyms:3-((2-methyl-1,3-thiazol-4-yl)ethynyl)pyridine;MTEP compound

Suppliers and Price of 2-Methyl-4-(pyridin-3-ylethynyl)thiazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
MTEP
5mg
$ 307.00

Sigma-Aldrich
mGluR5 Antagonist, MTEP - CAS 329205-68-7 - Calbiochem
5mg
$ 135.00

Matrix Scientific
3-[2-(2-Methyl-1,3-thiazol-4-yl)ethynyl]pyridine
5g
$ 1260.00

Matrix Scientific
3-[2-(2-Methyl-1,3-thiazol-4-yl)ethynyl]pyridine
1g
$ 540.00

Matrix Scientific
3-[2-(2-Methyl-1,3-thiazol-4-yl)ethynyl]pyridine
10g
$ 1764.00

Biosynth Carbosynth
MTEP
10 mg
$ 85.00

Biosynth Carbosynth
MTEP
50 mg
$ 297.50

American Custom Chemicals Corporation
MTEP 95.00%
5G
$ 2841.30

American Custom Chemicals Corporation
MTEP 95.00%
5MG
$ 228.80

American Custom Chemicals Corporation
MTEP 95.00%
1G
$ 1270.50

Total 6 raw suppliers

Chemical Property of 2-Methyl-4-(pyridin-3-ylethynyl)thiazole

Chemical Property:

PSA：54.02000
LogP:2.24630
XLogP3:2.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:200.04081944
Heavy Atom Count:14
Complexity:253

Purity/Quality:

98%,99%, ^*data from raw suppliers

MTEP ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CC1=NC(=CS1)C#CC2=CN=CC=C2

Technology Process of 2-Methyl-4-(pyridin-3-ylethynyl)thiazole

There total 2 articles about 2-Methyl-4-(pyridin-3-ylethynyl)thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 626-55-1,163928-56-1
3-Bromopyridine

: 329203-85-2
2-methyl-4-[(trimethylsilyl)ethynyl]-1,3-thiazole

: 329205-68-7
3-[(2-methyl-4-thiazolyl)ethynyl]pyridine

Guidance literature:: With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutyl ammonium fluoride; diisopropylamine; In tetrahydrofuran; Reflux;
DOI:10.1002/jps.21823

Reference yield: 52.0%

: 1120-90-7
3-iodopyridine

: 329203-85-2
2-methyl-4-[(trimethylsilyl)ethynyl]-1,3-thiazole

: 329205-68-7
3-[(2-methyl-4-thiazolyl)ethynyl]pyridine

Guidance literature:: With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; tetrabutyl ammonium fluoride; In tetrahydrofuran; N,N-dimethyl-formamide; at 85 ℃; for 0.25h;
DOI:10.1021/jm050570f