2,6-Piperidinedione, 3-[(4-methylphenyl)sulfonyl]-1-(phenylmethyl)-

Base Information

Chemical Name:2,6-Piperidinedione, 3-[(4-methylphenyl)sulfonyl]-1-(phenylmethyl)-
CAS No.:330173-10-9
Molecular Formula:C19H19NO4S
Molecular Weight:357.43
Hs Code.:
DSSTox Substance ID:DTXSID80477175
Nikkaji Number:J1.449.754D

Synonyms:330173-10-9;2,6-Piperidinedione, 3-[(4-methylphenyl)sulfonyl]-1-(phenylmethyl)-;DTXSID80477175

Suppliers and Price of 2,6-Piperidinedione, 3-[(4-methylphenyl)sulfonyl]-1-(phenylmethyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2,6-Piperidinedione, 3-[(4-methylphenyl)sulfonyl]-1-(phenylmethyl)-

Chemical Property:

PSA：79.90000
LogP:3.50520
XLogP3:2.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:357.10347926
Heavy Atom Count:25
Complexity:595

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC=C(C=C1)S(=O)(=O)C2CCC(=O)N(C2=O)CC3=CC=CC=C3

Technology Process of 2,6-Piperidinedione, 3-[(4-methylphenyl)sulfonyl]-1-(phenylmethyl)-

There total 10 articles about 2,6-Piperidinedione, 3-[(4-methylphenyl)sulfonyl]-1-(phenylmethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 292638-85-8,9003-21-8,96-33-3
acrylic acid methyl ester

: 330173-08-5
N-benzyl-2-(4-methylphenylsulfonyl)acetamide

: 330173-10-9
1-benzyl-3-(4-methylphenylsulfonyl)piperidine-2,6-dione

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 25 ℃;
DOI:10.1016/S0040-4039(00)01845-1

Reference yield: 81.0%

: 1-benzyl-3-bromo-3-(4-methylphenylsulfonyl)piperidine-2,6-dione

: 330173-10-9
1-benzyl-3-(4-methylphenylsulfonyl)piperidine-2,6-dione

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; for 0.166667h; Heating;
DOI:10.1002/jccs.200200145

Reference yield:

: 2564-06-9
N-benzyl-2-chloroacetamide

: 330173-10-9
1-benzyl-3-(4-methylphenylsulfonyl)piperidine-2,6-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 74 percent / dioxane; H₂O / 12 h / Heating

2: NaH / tetrahydrofuran / 12 h / 20 °C

With sodium hydride; In tetrahydrofuran; 1,4-dioxane; water;
DOI:10.1021/jo025539p