330173-08-5

Basic information

• Product Name: Acetamide, 2-[(4-methylphenyl)sulfonyl]-N-(phenylmethyl)-
• CAS NO: 330173-08-5
• Molecular Formula: C16H17NO3S
• Molecular Weight: 303.382
• Mol File: 330173-08-5.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Acetamide, 2-[(4-methylphenyl)sulfonyl]-N-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, 2-[(4-methylphenyl)sulfonyl]-N-(phenylmethyl)-(330173-08-5)
• EPA Substance Registry System: Acetamide, 2-[(4-methylphenyl)sulfonyl]-N-(phenylmethyl)-(330173-08-5)

Safety Data

• Hazardous Substances Data: 330173-08-5(Hazardous Substances Data)

Upstream product

• 2564-06-9 N-benzyl-2-chloroacetamide 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 657-84-1 sodium tosylate 
• 79-04-9 chloroacetyl chloride 
• 100-46-9 benzylamine 

Downstream Products

• 330173-28-9 1-benzyl-3-phenyl-5-(toluene-4-sulfonyl)-piperidine-2,6-dione 
• 330173-10-9 1-benzyl-3-(4-methylphenylsulfonyl)piperidine-2,6-dione 
• 1085449-68-8 (E)-N-benzyl-3-(2-chlorophenyl)-acrylamide 
• 1085449-61-1 (E)-N-benzyl-3-(4-bromophenyl)-acrylamide 
• 1085449-66-6 (E)-N-benzyl-3-(3-chlorophenyl)-acrylamide 
• 1085449-55-3 (E)-N-benzyl-3-(4-cyanophenyl)acrylamide 
• 1085449-53-1 (E)-N-benzyl-3-(2-nitrophenyl)acrylamide 
• 1085449-59-7 (E)-N-benzyl-3-(2-cyanophenyl)acrylamide 
• 1085449-51-9 (Z)-N-benzyl-3-(3-nitrophenyl)acrylamide 
• 1085449-49-5 (E)-N-benzyl-3-(3-nitrophenyl)acrylamide 
• 1041867-94-0 3-(4-nitrophenyl)-N-(phenylmethyl)-2-propenamide 
• 1085449-63-3 (E)-N-benzyl-3-(2-bromophenyl)acrylamide 
• 330173-16-5 1-benzyl-3-(4-methylphenylsulfonyl)-5-methylpiperidine-2,6-dione 

Relevant articles and documents

Synthesis of (±)-rolipram

A facile synthesis of rolipram via stepwise [3+2] annulation and desulfonated hydrolysis was reported. Base-induced coupling/cyclization reactions of α-sulfonylacetamide with (Z)-2-bromoacrylic ester yielded three contiguous centers on the pyroglutamate system with trans-trans orientation as the one-pot key step.

Synthesis of fused bicyclic glutarimides

We describe an efficient route towards the synthesis of fused bicyclic glutarimides using facile [3+3] reaction of α-sulfonylacetamides with different α,β-unsaturated esters as the key step. Intramolecular cyclization of 4-substituted 3-sulfonylglutarimide to form 5,6-, 6,6- or 6,7-fused bicyclic glutarimides was accomplished via alkylation, oxidative cyclization or ring-closing metathesis in modest yield.

Regioselective reduction of 3-sulfonyl glutarimides to 3,4-dihydro-5-sulfonylpyridin-2-ones. Formal synthesis of the indolizidine 8a-epi-dendroprimine

Sodium borohydride regioselectively reduced various 3-sulfonyl glutarimides 1 to hydroxy piperidones 2, which were further dehydrated to 3,4-dihydro-5-sulfonylpyridin-2-ones 3 in the presence of boron trifluoride. Formal synthesis of 8a-epi-dendroprimine (4) possessing an indolizidine ring system has been accomplished via intramolecular radical cyclization of cyclic vinyl sulfone 5.