2-Oxazolidinone, 5-[(triphenylmethoxy)methyl]-, (5S)-

Base Information

Chemical Name:2-Oxazolidinone, 5-[(triphenylmethoxy)methyl]-, (5S)-
CAS No.:330555-60-7
Molecular Formula:C23H21NO3
Molecular Weight:359.425
Hs Code.:
DSSTox Substance ID:DTXSID00465978
Nikkaji Number:J1.500.666H
Wikidata:Q82292316

Synonyms:2-Oxazolidinone, 5-[(triphenylmethoxy)methyl]-, (5S)-;330555-60-7;SCHEMBL3945289;DTXSID00465978

Suppliers and Price of 2-Oxazolidinone, 5-[(triphenylmethoxy)methyl]-, (5S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 0 raw suppliers

Chemical Property of 2-Oxazolidinone, 5-[(triphenylmethoxy)methyl]-, (5S)-

Chemical Property:

PSA：51.05000
LogP:3.74350
XLogP3:4.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:6
Exact Mass:359.15214353
Heavy Atom Count:27
Complexity:431

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1C(OC(=O)N1)COC(C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4
Isomeric SMILES:C1[C@H](OC(=O)N1)COC(C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4

Technology Process of 2-Oxazolidinone, 5-[(triphenylmethoxy)methyl]-, (5S)-

There total 4 articles about 2-Oxazolidinone, 5-[(triphenylmethoxy)methyl]-, (5S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 330555-58-3
(S)-3-hydroxy-4-triphenylmethoxybutanamide

: 330555-60-7
(S)-5-triphenylmethoxymethyl-1,3-oxazolidin-2-one

Guidance literature:: With sodium hydroxide; sodium hypochlorite; In tetrahydrofuran; at 55 - 60 ℃; for 8h;
DOI:10.1016/S0957-4166(00)00438-9

Reference yield: 30.0%

: 113240-54-3
(3S)-3-hydroxy-4-O-triphenylmethyloxybutanoic acid

: 330555-60-7
(S)-5-triphenylmethoxymethyl-1,3-oxazolidin-2-one

Guidance literature:: (3S)-3-hydroxy-4-O-triphenylmethyloxybutanoic acid; With triethylamine; isobutyl chloroformate; In tetrahydrofuran; at -30 ℃; for 1h; Inert atmosphere;

With sodium azide; In water; at 0 ℃; for 1.5h; Cooling with ice;

In toluene; at 60 ℃; for 1.5h; Reflux;
DOI:10.1016/j.tet.2014.06.048

Reference yield:

: 76-83-5
trityl chloride

: 330555-60-7
(S)-5-triphenylmethoxymethyl-1,3-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / 6 h / 20 - 50 °C / Inert atmosphere

2.1: sodium hydroxide / water; tetrahydrofuran / 36 h / 20 °C

3.1: triethylamine; isobutyl chloroformate / tetrahydrofuran / 1 h / -30 °C / Inert atmosphere

3.2: 1.5 h / 0 °C / Cooling with ice

3.3: 1.5 h / 60 °C / Reflux

With pyridine; triethylamine; sodium hydroxide; isobutyl chloroformate; In tetrahydrofuran; water;
DOI:10.1016/j.tet.2014.06.048