330555-58-3

Upstream product

• 76-83-5 trityl chloride 
• 126495-84-9 (S)-3,4-dihydroxybutyramide 
• 65291-30-7 trityl glycidyl ether 
• 890050-54-1 3-hydroxy-4-triphenylmethoxybutanenitrile 
• 131666-63-2 (S)-3-hydroxy-4-triphenylmethoxybutanenitrile 

Downstream Products

• 330555-60-7 (S)-5-triphenylmethoxymethyl-1,3-oxazolidin-2-one 
• 841261-74-3 (2S)-4-amino-1-(triphenylmethoxy)-2-butanol 
• 637343-48-7 n-isopropyl-5-trityloxymethyl-2-oxazolidinone 
• 637343-44-3 (S)-3-(2-nitrophenyl)-5-trityloxymethy-2-oxazolidinone 
• 637343-45-4 (S)-3-(2,5-dimethoxyphenacyl)-5-trityloxymethyl-2-oxazolidinone 

Relevant academic research and scientific papers

A simple three-step method for preparing homochiral 5-trityloxymethyl-2-oxazolidinones from optically active 3-hydroxy-γ-butyrolactones

A simple high-yield three-step route to O-tritylated optically active 5-hydroxymethyl oxazolidinones from optically active 3-hydroxy-γ-butyrolactones is described. The key intermediate is the 4-O-trityl ether of homochiral 3,4-dihydroxybutyramide, which is obtained in quantitative yield from 3-hydroxy-γ-butyrolactone by treatment with ammonia. It is readily transformed to the oxazolidinone by Hoffmann rearrangement in a two-phase system. The carbonyl group in the oxazolidinone is derived from C-1 of the amide, and a separate carbonylation reaction is not required. Oxazolidinones are key compounds in drug synthesis especially in the areas of antibacterials and behavior disorder therapy.

Gold(I)-catalyzed, one-pot, oxidative formation of 2,4-disubstituted thiazoles: Application to the synthesis of a pateamine-related macrodiolide

Thiazoles are important heterocyclic motifs in many target molecules. Extension of a reported gold(I)-catalyzed oxidative coupling of alkynes and thioamides to the synthesis of functionalized thiazole-containing products is presented, including the compatibility of this reaction with ester, protected hydroxyl, alkene and thioether groups. The utility of this one-pot process is demonstrated in the preparation of the thiazole-containing macrodiolide of a simplified analogue of pateamine A.

Lipase-mediated resolution of 3-hydroxy-4-trityloxybutanenitrile: synthesis of 2-amino alcohols, oxazolidinones and GABOB

Lipase-mediated kinetic resolution of 3-hydroxy-4-trityloxybutanenitrile gave the (S)-alcohol and (R)-acetate in good yields and high enantioselectivities. The resolution using Pseudomonas cepacia lipase (Burkholderia cepacia) immobilized on modified cera

New synthesis of chiral 1,3-oxazinan-2-ones from carbohydrate derivatives

(Chemical Equation Presented) Chiral 1,3-oxazinan-2-ones are useful intermediates in synthesizing pharmaceutical compounds and amino alcohols. In this paper, we report a new synthetic method to chiral 6-hydroxymethyl 1,3-oxazinan-2-ones and their analogue

PROCESS FOR THE PREPARATION OF OXAZOLIDINONES AND METHOD OF USE THEREOF

A process for preparing N-(substituted)-C-- (substituted methyl)-oxazolidinones, C-(substituted methyl)-oxazolidinones, and N-(substituted)-C-- (substituted ethyl)-oxazolidinones, preferably chiral, from optically active C-(protected oxymethyl)- oxazolidi