6-Bromo-3-methylbenzofuran

Base Information

Chemical Name:6-Bromo-3-methylbenzofuran
CAS No.:33118-86-4
Molecular Formula:C9H7BrO
Molecular Weight:211.058
Hs Code.:
DSSTox Substance ID:DTXSID401311105

Synonyms:6-bromo-3-methylbenzofuran;33118-86-4;6-bromo-3-methyl-1-benzofuran;MFCD24387451;6-Bromo-3-methybenzofuran;SCHEMBL1530853;OYBVNCWGSQKOAH-UHFFFAOYSA-N;DTXSID401311105;AKOS005215964;AS-9997;SY294090;V10221

Suppliers and Price of 6-Bromo-3-methylbenzofuran

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 7 raw suppliers

Chemical Property of 6-Bromo-3-methylbenzofuran

Chemical Property:

XLogP3:3.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:0
Exact Mass:209.96803
Heavy Atom Count:11
Complexity:149

Purity/Quality:: 99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=COC2=C1C=CC(=C2)Br

Technology Process of 6-Bromo-3-methylbenzofuran

There total 2 articles about 6-Bromo-3-methylbenzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 30186-18-6
4'-bromo-2'-hydroxyacetophenone

: 33118-86-4
6-bromo-3-methyl-1-benzofuran

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH / 1.) DMF, 2.) DMF, RT, 4 h

2: 97 percent / 1N aq. NaOH / tetrahydrofuran / 3.5 h / Ambient temperature

3: 77 percent / NaOAc, Ac₂O / 17 h / Heating

With sodium hydroxide; sodium acetate; acetic anhydride; sodium hydride; In tetrahydrofuran;
DOI:10.1016/S0968-0896(96)00244-1

Reference yield:

: 30186-18-6
4'-bromo-2'-hydroxyacetophenone

: 96-32-2
bromoacetic acid methyl ester

: 33118-86-4
6-bromo-3-methyl-1-benzofuran

Guidance literature:: 4'-bromo-2'-hydroxyacetophenone; With sodium hydride; In N,N-dimethyl-formamide; at 25 ℃; for 18.5h;

bromoacetic acid methyl ester; With water; sodium hydroxide; In tetrahydrofuran; water; at 25 ℃; for 3h;

With sodium acetate; acetic anhydride; for 18h; Reflux;
DOI:10.1016/j.bmcl.2013.04.057

Reference yield: 67.0%

: 33118-86-4
6-bromo-3-methyl-1-benzofuran

: 144873-97-2
2-(N-triphenylmethyl-tetrazol-5-yl)-phenylboronic acid

: 188714-71-8
5-[2-(3-Methyl-benzofuran-6-yl)-phenyl]-1-trityl-1H-tetrazole

Guidance literature:: With palladium diacetate; potassium carbonate; triphenylphosphine; In tetrahydrofuran; 1,2-dimethoxyethane; for 5h; Heating;
DOI:10.1016/S0968-0896(96)00244-1