N-(4-methoxybenzyl)-N-((6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuran-3-yl)methyl)methanesulfonamide

Base Information

Chemical Name:N-(4-methoxybenzyl)-N-((6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuran-3-yl)methyl)methanesulfonamide
CAS No.:1132943-86-2
Molecular Formula:C₂₄H₃₀BNO₆S
Molecular Weight:471.382
Hs Code.:

Synonyms:N-(4-methoxybenzyl)-N-((6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuran-3-yl)methyl)methanesulfonamide

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Chemical Property of N-(4-methoxybenzyl)-N-((6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuran-3-yl)methyl)methanesulfonamide

Chemical Property:

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Technology Process of N-(4-methoxybenzyl)-N-((6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuran-3-yl)methyl)methanesulfonamide

There total 3 articles about N-(4-methoxybenzyl)-N-((6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuran-3-yl)methyl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1132943-86-2
N-(4-methoxybenzyl)-N-((6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuran-3-yl)methyl)methanesulfonamide

Guidance literature:

Reference yield:

: 30186-18-6
4'-bromo-2'-hydroxyacetophenone

: 1132943-86-2
N-(4-methoxybenzyl)-N-((6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuran-3-yl)methyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 18.5 h / 25 °C

1.2: 3 h / 25 °C

1.3: 18 h / Reflux

2.1: N-Bromosuccinimide; dibenzoyl peroxide / chlorobenzene / 2 h / Reflux

2.2: 3 h / 70 °C

2.3: 16 h / 80 °C

With N-Bromosuccinimide; sodium hydride; dibenzoyl peroxide; In N,N-dimethyl-formamide; chlorobenzene;
DOI:10.1016/j.bmcl.2013.04.057

Reference yield:

: 33118-86-4
6-bromo-3-methyl-1-benzofuran

: 42060-31-1
N-(4-methoxybenzyl)-methanesulfonamide

: 73183-34-3
bis(pinacol)diborane

: 1132943-86-2
N-(4-methoxybenzyl)-N-((6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuran-3-yl)methyl)methanesulfonamide

Guidance literature:: 6-bromo-3-methyl-1-benzofuran; With N-Bromosuccinimide; dibenzoyl peroxide; In chlorobenzene; for 2h; Reflux;

N-(4-methoxybenzyl)-methanesulfonamide; With potassium carbonate; In N,N-dimethyl-formamide; at 70 ℃; for 3h;

bis(pinacol)diborane; With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; In 1,4-dioxane; at 80 ℃; for 16h;
DOI:10.1016/j.bmcl.2013.04.057