8-[2-(DiphenylMethoxy)-N-MethylethylaMino]-1,3-diMethylxanthine

Base Information

• Chemical Name: 8-[2-(DiphenylMethoxy)-N-MethylethylaMino]-1,3-diMethylxanthine
• CAS No.: 33120-34-2
• Molecular Formula: C₂₃H₂₅N₅O₃
• Molecular Weight: 419.483
• Mol file: 33120-34-2.mol

Synonyms:8-(2-Diphenylmethoxy-N-methylethylamin)-1,3-dimethylxanthin;amentotaxus biflavone;4',4''',5,5'',7,7''-HEXAHYDROXY-3''',8-BIFLAVONE;I-3,II-8-biapigenin;8-[2-(diphenylmethoxy)ethylmethylamino]theophylline;AMENTOFLAVONE(SH);2,3-dihydroamentoflavone;8-[(2-benzhydryloxy-ethyl)-methyl-amino]-1,3-dimethyl-3,7(9)-dihydro-purine-2,6-dione;AMENTOFLACONE;8-(5,7,4'-trihydroxyflavone-3'-yl)-5,7,4'-trihydroxyflavone;8-[((5-(5,7-dihydroxyphenyl)-4-oxo-4H)-1-benzopyran-2-yl)-2-hydroxyphenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one;DIDEMETHYL-GINKGETIN;amenthoflavone;3',8''-BIAPIGENIN;

Chemical Property of 8-[2-(DiphenylMethoxy)-N-MethylethylaMino]-1,3-diMethylxanthine

Chemical Property:

• Melting Point: 203-206°C
• PSA: 85.15000
• LogP: 2.20270
• Storage Temp.: Room Temperature
• Solubility.: Chloroform (Slightly), Ethyl Acetate (Slightly)

Purity/Quality:

>95% ^*data from raw suppliers

8-[2-(Diphenylmethoxy)-N-methylethylamino]-1,3-dimethylxanthine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 8-[2-(Diphenylmethoxy)-N-methylethylamino]-1,3-dimethylxanthine is an impurity of Dimenhydrinate (D460520), an antihistamine with antiemetic properties used to prevent nausea and motion sicknes composed of two drugs 8-Chlorotheophylline (C411440) and Diphenhydramine (D486900).

Technology Process of 8-[2-(DiphenylMethoxy)-N-MethylethylaMino]-1,3-diMethylxanthine

There total 3 articles about 8-[2-(DiphenylMethoxy)-N-MethylethylaMino]-1,3-diMethylxanthine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

8-chlorotheophylline (85-18-7) + Desmethyldiphenhydramine (17471-10-2) → 8-[2-(diphenylmethoxy)ethylmethylamino]theophylline (33120-34-2)

Guidance literature:

In ethanol; for 336h; Heating;

DOI:10.1691/ph.2007.3.6156

Reference yield:

1,1'-[(2-chloroethoxy)methylene]bis-benzene (32669-06-0) → 8-[2-(diphenylmethoxy)ethylmethylamino]theophylline (33120-34-2)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 336 h / 20 °C

2: 10 percent / ethanol / 336 h / Heating

In ethanol;

DOI:10.1691/ph.2007.3.6156

Reference yield:

→ 8-[2-(diphenylmethoxy)ethylmethylamino]theophylline (33120-34-2)

Guidance literature:

Dimenhydrinat;

DOI:10.1002/jps.2600600540

upstream raw materials:

8-chlorotheophylline

Desmethyldiphenhydramine

1,1'-[(2-chloroethoxy)methylene]bis-benzene

Refernces

• 1、 Doege, Ulrica,Eger. "A simple HPLC-UV method for the determination of dimenhydrinate and related substances - Identification of an unknown impurity". . p. 174 - 178. Retrieved 2008/02/01.