32669-06-0Relevant articles and documents
Scouting new sigma receptor ligands: Synthesis, pharmacological evaluation and molecular modeling of 1,3-dioxolane-based structures and derivatives
Franchini, Silvia,Battisti, Umberto Maria,Prandi, Adolfo,Tait, Annalisa,Borsari, Chiara,Cichero, Elena,Fossa, Paola,Cilia, Antonio,Prezzavento, Orazio,Ronsisvalle, Simone,Aricò, Giuseppina,Parenti, Carmela,Brasili, Livio
, p. 1 - 19 (2016/02/19)
Herein we report the synthesis and biological activity of new sigma receptor (σR) ligands obtained by combining different substituted five-membered heterocyclic rings with appropriate σR pharmacophoric amines. Radioligand binding assay, performed on guine
Bronsted acid-catalyzed nucleophilic substitution of alcohols
Sanz, Roberto,Martinez, Alberto,Miguel, Delia,Alvarez-Gutierrez, Julia M.,Rodriguez, Felix
, p. 1841 - 1845 (2007/10/03)
Simple Bronsted acids such as p-toluene-sulfonic acid monohydrate (PTS) or polymer-bound p-toluenesulfonic acid efficiently catalyze the direct nucleophilic substitution of the hydroxy group of allylic and benzylic alcohols with a large variety of carbon- and heteroatom-centered nucleophiles. Reaction conditions are mild, the process is conducted under an atmosphere of air without the need for dried solvents, and water is the only side product of the reaction.
Linker arms for nanocrystals and compounds thereof
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, (2008/06/13)
A nanocrystal compound comprising: a nanocrystal, and attached thereto a compound of the following formula: n is 0 or an integer from 1 to 48; X and Z are independently O, NH, N—R, S, CH2, CO, COHN, NHCO, SO, SO2NH, NHSO2, carbamate and thio carbamate; R is alkyl or aryl; r is 0 or an integer from 1 to 15; and wherein S is the attachment point to a nanocrystal compound. The nanocrystal compounds of the present invention are useful fluorescent labels.
Oxygenated analogues of 1-[2-(diphenylmethoxy)ethyl]- and 1- [2- [bis (4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909) as potential extended-action cocaine-abuse therapeutic agents
Lewis, David B.,Matecka, Dorota,Zhang, Ying,Hsin, Ling-Wei,Dersch, Christina M.,Stafford, David,Glowa, John R.,Rothman, Richard B.,Rice, Kenner C.
, p. 5029 - 5042 (2007/10/03)
An investigation into the preparation of potential extended-release cocaine-abuse therapeutic agents afforded a series of compounds related to 1- [2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine (1a) and 1-[2-[bis(4- fluorophenyl)methoxy]ethyl]-4-(
Development of novel, potent, and selective dopamine reuptake inhibitors through alteration of the piperazine ring of 1-[2-(diphenylmethoxy)ethyl]- and 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909)
Matecka, Dorota,Rothman, Richard B.,Radesca, Lilian,De Costa, Brian R.,Dersch, Christina M.,Partilla, John S.,Pert, Agu,Glowa, John R.,Wojnicki, Francis H. E.,Rice, Kenner C.
, p. 4704 - 4716 (2007/10/03)
The design, synthesis, and biological evaluation of compounds related to the dopamine (DA) uptake inhibitors: 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine (1) and 1-[2-[bis-(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (2) (GBR
Various N-substituted 3-piperidine carboxylic acids or N-substituted 3-pyridinecarboxylic acids and derivatives thereof
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, (2008/06/13)
Analogs of nipecotic acid are the novel compounds of the present invention. The analogs are GABA uptake inhibitors for use to treat epilepsy and, thus, the invention is also pharmaceutical compositions and methods of use therefor.
Amide derivatives and 5-lipoxygenase inhibitors containing the same as an active ingredient
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, (2008/06/13)
According to the invention, there are provided novel amide derivatives and 5-lipoxygenase inhibitors containing the same as an effective ingredient. The above-mentioned compounds of the invention have been demonstrated to posses 5-lipoxygenase-inhibiting activities. These compounds can inhibit the production of leucotrienes such as LTC4 and LTD4 which are allergy-inducing factors by inhibiting the activity of 5-lipoxygenase. Accordingly, the amide derivatives can be used as 5-lipoxygenase inhibitors effective for allergic asthma, allergic rhinitis and the like.
Synthesis and psychoanaleptic properties of new compounds structurally related to diphenhydramine
Buzas,Champagnac,Dehnel,Lavielle,Pommier
, p. 149 - 153 (2007/10/02)
A new series of benzhydryloxyalkylpiperazines carrying a trivalent function has been synthesized and studied for its effects on the central nervous system. Most of the compounds exhibit unexpected nonamphetaminic psychoanaleptic properties. The structure-