N-(4-bromo-3-methylphenyl)acetamide

Base Information

• Chemical Name: N-(4-bromo-3-methylphenyl)acetamide
• CAS No.: 331-30-6
• Molecular Formula: C9H10FNO
• Molecular Weight: 167.183
• Mol file: 331-30-6.mol

Synonyms:N-acetyl-4-fluoro-3-methyl-aniline;Essigsaeure-(4-fluor-3-methyl-anilid);3-methyl-4-bromoacetanilide;acetic acid-(4-fluoro-3-methyl-anilide);N-(4-fluoro-3-methylphenyl)acetamide;

Chemical Property of N-(4-bromo-3-methylphenyl)acetamide

Chemical Property:

• PSA: 29.10000
• LogP: 2.16550

Purity/Quality:

97% ^*data from raw suppliers

n-(4-fluoro-3-methylphenyl)acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(4-bromo-3-methylphenyl)acetamide

There total 4 articles about N-(4-bromo-3-methylphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-methyl-4-fluoroaniline (452-69-7) + acetic anhydride (108-24-7) → N-acetyl-4-fluoro-3-methylbenzenamine (331-30-6)

Guidance literature:

at 0 ℃; for 1h;

Reference yield: 71.0%

C9H10FNO → N-acetyl-4-fluoro-3-methylbenzenamine (331-30-6)

Guidance literature:

With 10-methyl-9-phenylacridin-10-ium perchlorate; In 1,2-dichloro-ethane; at 20 ℃; for 5h; Irradiation; Sealed tube;

DOI:10.1021/acs.orglett.0c02168

Reference yield: 53.0%

1-(4-fluoro-3-methyl-phenyl)-ethanone oxime (403-00-9) → N-acetyl-4-fluoro-3-methylbenzenamine (331-30-6)

Guidance literature:

With 1,1,1,3',3',3'-hexafluoro-propanol; tetrabutylammonium tetrafluoroborate; water; In 1,2-dichloro-ethane; at 20 ℃; for 0.8h; Electrochemical reaction;

DOI:10.1002/cssc.202001553

upstream raw materials:

1-(4-fluoro-3-methyl-phenyl)-ethanone oxime

3-methyl-4-fluoroaniline

acetic anhydride

5-nitro-2-fluorotoluene

Downstream raw materials:

3-methyl-4-fluoroaniline

N-acetyl-4-fluoro-5-methyl-2-nitrobenzenamine

N-acetyl-4-fluoro-3-methyl-2-nitrobenzenamine

2-amino-3,4,8-trimethylimidazo-[4,5-f]quinoxaline