452-69-7

Basic information

• Product Name: 2-Fluoro-5-aminotoluene
• Synonyms: 5-AMINO-2-FLUOROTOLUENE;4-FLUORO-3-METHYLANILINE;4-FLUORO-M-TOLUIDINE;2-FLUORO-5-AMINOTOLUENE;Benzenamine, 4-fluoro-3-methyl-;5-Amino-2-fluorotoluene~4-Fluoro-m-toluidine;Fluoromethylaniline6;4-fluoro-3-methylbenzenamine
• CAS NO: 452-69-7
• Molecular Formula: C₇H₈FN
• Molecular Weight: 125.14
• EINECS: 207-207-7
• Product Categories: Fluorin-contained toluene series;Fluorobenzene;Aromatic Hydrocarbons (substituted) & Derivatives;Anilines, Aromatic Amines and Nitro Compounds;Aniline;Miscellaneous;Amines;Aryl Fluorinated Building Blocks;Building Blocks;C7;C7-C8;Chemical Synthesis;Fluorinated Building Blocks;Nitrogen Compounds;Organic Building Blocks;Organic Fluorinated Building Blocks;Other Fluorinated Organic Building Blocks
• Mol File: 452-69-7.mol
• Article Data: 7

Chemical Properties

• Melting Point: 35 °C
• Boiling Point: 85-86°C 9mm
• Flash Point: 95°C
• Appearance: /
• Density: 1,12 g/cm3
• Vapor Pressure: 0.172mmHg at 25°C
• Refractive Index: 1.5370
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• PKA: 4.78±0.10(Predicted)
• BRN: 2935561
• CAS DataBase Reference: 2-Fluoro-5-aminotoluene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Fluoro-5-aminotoluene(452-69-7)
• EPA Substance Registry System: 2-Fluoro-5-aminotoluene(452-69-7)

Safety Data

• Hazard Codes: Xi,T
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39-36-27
• RIDADR: 2811
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 452-69-7(Hazardous Substances Data)

Usage

Chemical Properties

White to brown or violet solid

Uses

4-Fluoro-3-methylaniline may be used to synthesize 4-methoxy-3′-methyl-4′-fluorobiphenyl and diimine Schiff bases.

InChI:InChI=1/C7H7FO/c1-5-4-6(9)2-3-7(5)8/h2-4,9H,1H3

Upstream product

• 51437-00-4 5-bromo-2-fluorotoluene 
• 125620-28-2 Pd-C 
• 455-88-9 5-nitro-2-fluorotoluene 
• 403-00-9 1-(4-fluoro-3-methyl-phenyl)-ethanone oxime 
• 99-08-1 1-methyl-3-nitrobenzene 
• 331-30-6 N-acetyl-4-fluoro-3-methylbenzenamine 

Downstream Products

• 57730-02-6 (2,4-Dinitro-6-trifluoromethyl-phenyl)-(4-fluoro-3-methyl-phenyl)-amine 
• 871261-03-9 C₁₄H₁₆FNO₅S 
• 955314-42-8 2-cyano-N-(4-fluoro-3-methylphenyl)acetamide 
• 937817-30-6 N-(2-acetyl-4-fluoro-5-methylphenyl)glycine 
• 937817-52-2 (2-acetyl-4-fluoro-5-methylphenylamino)acetic acid ethyl ester 
• 937816-84-7 1-(2-amino-5-fluoro-4-methylphenyl)ethanone 
• 819056-79-6 N-(4-fluoro-3-methylphenyl)-N'-[4-(4,4,5,5-tetramethyl-[1,3,2]-dioxaborolan-2-yl)phenyl]urea 

Relevant articles and documents

AMINATION AND HYDROXYLATION OF ARYLMETAL COMPOUNDS

In one aspect, the present disclosure provides methods of preparing a primary or secondary amine and hydroxylated aromatic compounds. In some embodiments, the aromatic compound may be unsubstituted, substituted, or contain one or more heteroatoms within the rings of the aromatic compound. The methods described herein may be carried out without the need for transition metal catalysts or harsh reaction conditions.

Dialkylimidazole inhibitors of Trypanosoma cruzi sterol 14α-demethylase as anti-Chagas disease agents

New dialkylimidazole based sterol 14α-demethylase inhibitors were prepared and tested as potential anti-Trypanosoma cruzi agents. Previous studies had identified compound 2 as the most potent and selective inhibitor against parasite cultures. In addition, animal studies had demonstrated that compound 2 is highly efficacious in the acute model of the disease. However, compound 2 has a high molecular weight and high hydrophobicity, issues addressed here. Systematic modifications were carried out at four positions on the scaffold and several inhibitors were identified which are highly potent (EC50 1 nM) against T. cruzi in culture. The halogenated derivatives 36j, 36k, and 36p, display excellent activity against T. cruzi amastigotes, with reduced molecular weight and lipophilicity, and exhibit suitable physicochemical properties for an oral drug candidate.

Endothelin antagonists

A compound of the formula (I): or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.