(R)-Methyl-phosphonic acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-methoxy-tetrahydro-furan-3-yl ester 2,2,2-trifluoro-1-trifluoromethyl-ethyl ester

Base Information

• Chemical Name: (R)-Methyl-phosphonic acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-methoxy-tetrahydro-furan-3-yl ester 2,2,2-trifluoro-1-trifluoromethyl-ethyl ester
• CAS No.: 191786-72-8
• Molecular Formula: C₄₃H₄₀F₆N₅O₉P
• Molecular Weight: 915.783

Synonyms:

Chemical Property of (R)-Methyl-phosphonic acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-methoxy-tetrahydro-furan-3-yl ester 2,2,2-trifluoro-1-trifluoromethyl-ethyl ester

Chemical Property:

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Safty Information:

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Useful:

Technology Process of (R)-Methyl-phosphonic acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-methoxy-tetrahydro-furan-3-yl ester 2,2,2-trifluoro-1-trifluoromethyl-ethyl ester

There total 1 articles about (R)-Methyl-phosphonic acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-methoxy-tetrahydro-furan-3-yl ester 2,2,2-trifluoro-1-trifluoromethyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,1,1,3',3',3'-hexafluoro-propanol (920-66-1) + C46H53N6O7P → (S)-Methyl-phosphonic acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-methoxy-tetrahydro-furan-3-yl ester 2,2,2-trifluoro-1-trifluoromethyl-ethyl ester + (R)-Methyl-phosphonic acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-methoxy-tetrahydro-furan-3-yl ester 2,2,2-trifluoro-1-trifluoromethyl-ethyl ester (191786-72-8)

Guidance literature:

With pyridine; 1H-tetrazole; iodine; Yield given. Multistep reaction. Yields of byproduct given; 1.) CH₃CN, room temperature, 3 min, 2.) THF, H₂O, room temperature, 20 min;

DOI:10.1080/07328319708001359

Reference yield:

N-{9-[(2R,3R,4R,5R)-4-(tert-Butyl-diphenyl-silanyloxy)-5-hydroxymethyl-3-methoxy-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide + (R)-Methyl-phosphonic acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-methoxy-tetrahydro-furan-3-yl ester 2,2,2-trifluoro-1-trifluoromethyl-ethyl ester (191786-72-8) → (R)-Methyl-phosphonic acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-methoxy-tetrahydro-furan-3-yl ester (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-3-hydroxy-4-methoxy-tetrahydro-furan-2-ylmethyl ester + (S)-Methyl-phosphonic acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-methoxy-tetrahydro-furan-3-yl ester (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-3-hydroxy-4-methoxy-tetrahydro-furan-2-ylmethyl ester

Guidance literature:

With 3-ethyl-3-pentanoxymagnesium chloride; tetrabutyl ammonium fluoride; Yield given. Multistep reaction. Yields of byproduct given; 1.) THF, 60-65 deg C, 2.) THF, room temperature, 2 h;

DOI:10.1080/07328319708001359

Reference yield:

N-{1-[(2R,3R,4R,5R)-4-(tert-Butyl-diphenyl-silanyloxy)-5-hydroxymethyl-3-methoxy-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-isobutyramide + (R)-Methyl-phosphonic acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-methoxy-tetrahydro-furan-3-yl ester 2,2,2-trifluoro-1-trifluoromethyl-ethyl ester (191786-72-8) → C54H59N8O14P + C54H59N8O14P

Guidance literature:

With 3-ethyl-3-pentanoxymagnesium chloride; tetrabutyl ammonium fluoride; Yield given. Multistep reaction. Yields of byproduct given; 1.) THF, 60-65 deg C, 2.) THF, room temperature, 2 h;

DOI:10.1080/07328319708001359

upstream raw materials:

1,1,1,3',3',3'-hexafluoro-propanol

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