1-Piperidinecarboxylic acid, 4-[[4-(aminocarbonyl)phenyl]methyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:1-Piperidinecarboxylic acid, 4-[[4-(aminocarbonyl)phenyl]methyl]-, 1,1-dimethylethyl ester
CAS No.:333795-10-1
Molecular Formula:C18H26N2O3
Molecular Weight:318.416
Hs Code.:

Synonyms:tert-butyl 4-(4-carbamoylbenzyl)piperidine-1-carboxylate;4-(4-Carbamoyl-benzyl)-piperidine-1-carboxylic acid tert-butyl ester;tert-Butyl 4-[4-(Aminocarbonyl)benzyl]-1-piperidinecarboxylate;

Suppliers and Price of 1-Piperidinecarboxylic acid, 4-[[4-(aminocarbonyl)phenyl]methyl]-, 1,1-dimethylethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 5 raw suppliers

Chemical Property of 1-Piperidinecarboxylic acid, 4-[[4-(aminocarbonyl)phenyl]methyl]-, 1,1-dimethylethyl ester

Chemical Property:

Melting Point:144 - 145 °C
PSA：72.63000
LogP:3.61330

Purity/Quality:: ≥99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of 1-Piperidinecarboxylic acid, 4-[[4-(aminocarbonyl)phenyl]methyl]-, 1,1-dimethylethyl ester

There total 3 articles about 1-Piperidinecarboxylic acid, 4-[[4-(aminocarbonyl)phenyl]methyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 147969-86-6
4-{[1-(tert-Butoxycarbonyl)-4-piperidinyl]methyl}benzoic acid

: 333795-10-1
tert-Butyl 4-[4-(aminocarbonyl)benzyl]-1-piperidinecarboxylate

Guidance literature:: With ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 20h;
DOI:10.1021/jm051034q

Reference yield:

: 2417-72-3
Methyl 4-(bromomethyl)benzoate

: 333795-10-1
tert-Butyl 4-[4-(aminocarbonyl)benzyl]-1-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 69 percent / 24 h / 150 °C

2: 91 percent / 1-hydroxybenzotriazole*H₂O; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl; ammonium chloride / Et₃N / dimethylformamide / 20 h / 20 °C

With ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; 1: Arbuzov reaction;
DOI:10.1021/jm051034q

Reference yield:

: 14295-52-4
4-(diethyoxyphosphorylmethyl)benzoic acid methyl ester

: 333795-10-1
tert-Butyl 4-[4-(aminocarbonyl)benzyl]-1-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / 1-hydroxybenzotriazole*H₂O; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl; ammonium chloride / Et₃N / dimethylformamide / 20 h / 20 °C

With ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1021/jm051034q