CarbaMic acid, N-[2-[[(4-chlorophenyl)Methyl]aMino]ethyl]-, 1,1-diMethylethyl ester

Base Information

• Chemical Name: CarbaMic acid, N-[2-[[(4-chlorophenyl)Methyl]aMino]ethyl]-, 1,1-diMethylethyl ester
• CAS No.: 335059-94-4
• Molecular Formula: C14H21ClN2O2
• Molecular Weight: 284.786
• Hs Code.: 2922390090
• Mol file: 335059-94-4.mol

Synonyms:tert-butyl {2-[(4-chlorobenzyl)amino]ethyl}carbamate;[2-(4-chlorobenzylamino)-ethyl]-carbamic acid tert-butyl ester;CARBAMIC ACID, N-[2-[[(4-CHLOROPHENYL)METHYL]-AMINO]ETHYL]-, 1,1-DIMETHYLETHYL ESTER;tert-butyl 2-(4-chlorobenzylamino)ethylcarbamate;

Chemical Property of CarbaMic acid, N-[2-[[(4-chlorophenyl)Methyl]aMino]ethyl]-, 1,1-diMethylethyl ester

Chemical Property:

• PSA: 50.36000
• LogP: 3.73610

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl {2-[(4-chlorobenzyl)amino]ethyl}carbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of CarbaMic acid, N-[2-[[(4-chlorophenyl)Methyl]aMino]ethyl]-, 1,1-diMethylethyl ester

There total 3 articles about CarbaMic acid, N-[2-[[(4-chlorophenyl)Methyl]aMino]ethyl]-, 1,1-diMethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

N-BOC-1,2-diaminoethane (57260-73-8) + 4-chlorobenzaldehyde (104-88-1) → [2-(4-chlorobenzylamino)ethyl]carbamic acid tert-butyl ester (335059-94-4)

Guidance literature:

With sodium tris(acetoxy)borohydride; acetic acid; In 1,1-dichloroethane; at 20 ℃;

Reference yield:

C14H19ClN2O2 (215654-54-9) → [2-(4-chlorobenzylamino)ethyl]carbamic acid tert-butyl ester (335059-94-4)

Guidance literature:

With sodium tetrahydroborate; triethylamine; In methanol; at 0 ℃; for 0.5h;

DOI:10.1016/j.bmc.2009.12.044

Reference yield:

N-BOC-1,2-diaminoethane (57260-73-8) + 1-Chloro-4-(chloromethyl)benzene (104-83-6) → [2-(4-chlorobenzylamino)ethyl]carbamic acid tert-butyl ester (335059-94-4)

Guidance literature:

With triethylamine; In acetonitrile; at 80 ℃;

DOI:10.1016/S0960-894X(00)00610-7

upstream raw materials:

N-BOC-1,2-diaminoethane

1-Chloro-4-(chloromethyl)benzene

4-chlorobenzaldehyde

C₁₄H₁₉ClN₂O₂

Downstream raw materials:

benzyl 4-((2-(tert-butoxycarbonylamino)ethyl)(4-chlorobenzyl)carbamoyl)piperazine-1-carboxylate

1-(4-chlorobenzyl)imidazolidin-2-one

N-(2-amino-ethyl)-N-(4-chlorobenzyl)-4-pyridin-4-yl-benzamide

{2-[(4-chlorobenzyl)-(4-pyridin-4-yl-benzoyl)-amino]-ethyl}-carbamic acid tert-butyl ester