57260-73-8

Basic information

• Product Name: N-Boc-Ethylenediamine
• Synonyms: (2-AMINO-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER;1-BOC-ETHYLENEDIAMINE;1-BOC-AMINO-1,2-ETHANEDIAMINE;AKOS 91563;BUTTPARK 27\08-29;BOC-EDA;BOC-DIAMINOETHANE;BOC-NH-(CH2)2-NH2
• CAS NO: 57260-73-8
• Molecular Formula: C₇H₁₆N₂O₂
• Molecular Weight: 160.21
• EINECS: 1312995-182-4
• Product Categories: N-BOC;Amines;blocks;Amines and Anilines;Aliphatics;Nitric Oxide Reagents;Exciton Chirality CD Methodfor (for Monofunctional Compounds);Monoprotected Diaminoalkanes;N-Boc-diaminoalkanes;Absolute Configuration Determination (Exciton Chirality CD Method);Analytical Chemistry;Enantiomer Excess & Absolute Configuration Determination;Cross Linking Reagents
• Mol File: 57260-73-8.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 72-80 °C0.1 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: Clear colorless to very light yellow/Oily Liquid
• Density: 1.012 g/mL at 20 °C(lit.)
• Vapor Pressure: 0.019mmHg at 25°C
• Refractive Index: n20/D 1.458(lit.)
• Storage Temp.: Refrigerator (+4°C)
• PKA: 12.40±0.46(Predicted)
• Water Solubility: Miscible with methanol and chloroform. Slightly miscible with water.
• Sensitive: Air Sensitive
• BRN: 1932330
• CAS DataBase Reference: N-Boc-Ethylenediamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Boc-Ethylenediamine(57260-73-8)
• EPA Substance Registry System: N-Boc-Ethylenediamine(57260-73-8)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 2735 8/PG 3
• WGK Germany: 3
• F: 10-34
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 57260-73-8(Hazardous Substances Data)

Usage

Chemical Properties

Clear colorless to very light yellow oily liquid

Uses

Different sources of media describe the Uses of 57260-73-8 differently. You can refer to the following data:
1. suzuki reaction
2. N-Boc-ethylenediamine is used in the synthesis of Thyronamine derivatives and analogs.
3. N-Boc-ethylenediamine is used in the synthesis of thyronamine derivatives. It is also used in the preparation of (2-isothiocyanato-ethyl)-carbamic acid tert-butyl ester by reacting with carbon disulfide. Further, it is used in both oligonucleotide and peptide synthesis.

InChI:InChI=1/C7H16N2O2/c1-7(2,3)11-6(10)9-5-4-8/h4-5,8H2,1-3H3,(H,9,10)

Upstream product

• 107-15-3 ethylenediamine 
• 322474-21-5 N,N'-bis-Boc-S-methyl-isothiourea 
• 636795-25-0 3-fluoro-4-(4-trifluoromethyl-benzyloxy)-benzoic acid 
• 58632-95-4 2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 34046-07-6 N-benzyloxycarbonyl-N-(2-t.butoxycarbonylaminoethyl)glycine 
• 137743-46-5 2-tert-butyloxycarbonylaminoethyl isothiocyanate 
• 126813-46-5 N-<2-<<(1-dimethylethoxy)carbonyl>amino>ethyl>-4-chloro-3-nitrobenzenesulfonamide 
• 153802-38-1 [(S)-2-tert-Butoxy-1-(2-tert-butoxycarbonylamino-ethylcarbamoyl)-ethyl]-carbamic acid benzyl ester 
• 77153-07-2 S-methyl-N-<2-<(tert-butoxycarbonyl)amino>ethyl>-N'-tosylisothiourea 
• 92741-56-5 N-<2'-(N''-Z-2-aminoethyl)-2,4'-bithiazole-4-carboxy>-N'-Boc-1,2-diaminoethane 
• 117498-75-6 <4-<<2-<(tert-butoxycarbonyl)amino>ethyl>amino>-3-nitrophenyl>(2-thienyl)methanone 
• 117498-54-1 (4-amino-3-nitrophenyl)<4-<ethyl>carbamoyl>methyl>2-thienyl>methanone 
• 90013-30-2 N²-benzyloxycarbonyl-N⁴-(2-tert-butoxycarbonylaminoethyl)-L-asparagine p-nitrobenzyl ester 
• 117861-32-2 <(β-mercapto-β,β-pentamethylenepropionyl)>D-Tyr(Et)-Phe-Val-Asn-Cys-Pro-NH(CH2)2NH2 
• 144510-94-1 6,9-bis<<2-ethyl>amino>benzoisoquinoline-5,10-dione 
• 154384-92-6 6-<<2-(t-butoxycarbonylamino)ethyl>amino>-9-<(4-methylphenyl)sulfonyloxy>benzophthalazine-5,10-dione 
• 72648-80-7 ethyl 2-[2-(tert-butoxycarbonylamino)ethyl-[3-[[4-(4,5-difluoro-2-methylsulfanyl-phenyl)phenoxy]methyl]benzoyl]amino]acetate 
• 166410-28-2 N-(tert-butyloxycarbonyl)-N'-(9H-fluoren-9-ylmethoxycarbonyl)-1,2-diaminoethane 

Relevant articles and documents

Formation of a tris(catecholato) iron(iii) complex with a nature-inspired cyclic peptoid ligand

Siderophore-mimicking macrocyclic peptoids were synthesized. Peptoid3with intramolecular hydrogen bonds showed an optimally arranged primary coordination sphere leading to a stable catecholate-iron complex. The tris(catecholato) structure of 3-Fe(iii) was determined with UV-vis, fluorescence, and EPR spectroscopies and DFT calculations. The iron binding affinity was comparable to that of deferoxamine, with enhanced stability upon air exposure.

An inorganic phosphate (Pi) sensor triggers 'turn-on' fluorescence response by removal of a Cu2+ ion from a Cu 2+-ligand sensor: Determination of Pi in biological samples

A fluorescent ligand that displays a high selectivity for Cu2+ has been synthesized. On complexation with Cu2+, the fluorescence of the ligand is quenched. Inorganic phosphate ions decomplex Cu2+ displaying a fluorescence enhancement that can even be seen with naked eyes. The method was successfully used in quantitative determination of inorganic phosphates in serum, urine, and saliva samples.

Synthesis and photoluminescence study of di-dendron dendrimers derived from mono-Boc-protected ethylenediamine cores

This work is focused on the synthesis and optical properties of cone-shaped structural feature di-dendron polyamidoamine dendrimers up to the third generation with mono-Boc-protected ethylenediamine (EDA) as a core. Strong UV absorbance spectra and fluorescence spectra from di-dendron dendrimers with different terminal groups (-NH2, -COOCH3) were studied under different conditions by varying experimental parameters such as concentration and pH. The optical density and fluorescence intensities increased when di-dendron dendrimers generation number increased from 0.5 to 3.0. It was confirmed that the concentration of di-dendron dendrimers plays an important role in fluorescence intensity. The increase in fluorescence intensity was linear in low concentration regions, but the intensity increased slowly in high concentration regions. The results also showed a rapid increase in fluorescence intensity at low pH. The formation of a fluorescence-emitting moiety had a close relationship to protonated tertiary amine groups in di-dendron dendrimers derived from mono-Boc-protected EDA cores. Furthermore, the formation of fluorescent chemical species was irreversible. Copyright