Butanoic acid, 4-[(2-furanylmethyl)amino]-4-oxo-

Base Information

• Chemical Name: Butanoic acid, 4-[(2-furanylmethyl)amino]-4-oxo-
• CAS No.: 335216-97-2
• Molecular Formula: C₉H₁₁NO₄
• Molecular Weight: 197.191
• Mol file: 335216-97-2.mol

Synonyms:N-Furan-2-ylmethyl-succinamic acid;N-furan-2-ylmethyl succinamic acid;

Chemical Property of Butanoic acid, 4-[(2-furanylmethyl)amino]-4-oxo-

Chemical Property:

• PSA: 79.54000
• LogP: 1.15150

Purity/Quality:

98%min ^*data from raw suppliers

4-[(furan-2-ylmethyl)amino]-4-oxobutanoicAcid ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

Useful:

Technology Process of Butanoic acid, 4-[(2-furanylmethyl)amino]-4-oxo-

There total 1 articles about Butanoic acid, 4-[(2-furanylmethyl)amino]-4-oxo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

succinic acid anhydride (108-30-5) + furan-2-ylmethanamine (617-89-0) → 4-(2-furylmethylamino)-4-oxo-butanoic acid (335216-97-2)

Guidance literature:

In dichloromethane; at 20 ℃; for 3h;

DOI:10.1039/b204790j

Reference yield:

1-(3-chloro-benzyl)-N,N-dimethylcyclohexane-1,4-diamine (869747-21-7) + 4-(2-furylmethylamino)-4-oxo-butanoic acid (335216-97-2) → N-[4-(3-chlorobenzyl)-4-dimethylaminocyclohexyl]-N'-furan-2-ylmethylsuccinic acid amide hydrochloride

Guidance literature:

1-(3-chloro-benzyl)-N,N-dimethylcyclohexane-1,4-diamine; 4-(2-furylmethylamino)-4-oxo-butanoic acid; With benzotriazol-1-ol; diisopropyl-carbodiimide; In DMF (N,N-dimethyl-formamide); at 0 - 20 ℃;

With sodium carbonate; In DMF (N,N-dimethyl-formamide); pH=> 10;

With chloro-trimethyl-silane; water; In methanol; ethyl acetate; butanone;

Reference yield:

5-(3-aminopropynyl)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyuridine (339569-43-6) + 4-(2-furylmethylamino)-4-oxo-butanoic acid (335216-97-2) → N-[3-(1-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-prop-2-ynyl]-N'-furan-2-ylmethyl-succinamide (908138-99-8)

Guidance literature:

With 1,1'-carbonyldiimidazole;

DOI:10.1081/NCN-200060085

upstream raw materials:

succinic acid anhydride

furan-2-ylmethanamine

Downstream raw materials:

N-[3-(1-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-prop-2-ynyl]-N'-furan-2-ylmethyl-succinamide

Refernces

• 1、 England, Richard M.,Moss, Jennifer I.,Gunnarsson, Anders,Parker, Jeremy S.,Ashford, Marianne B.. "Synthesis and Characterization of Dendrimer-Based Polysarcosine Star Polymers: Well-Defined, Versatile Platforms Designed for Drug-Delivery Applications". . p. 3332 - 3341. Retrieved 2020.
• 2、 Di Yang, Meng,Shen, Xiao Bao,Hu, Yang Sheng,Chen, Yan Yan,Liu, Xin Hua. "Novel naphthalene-enoates: Design and anticancer activity through regulation cell autophagy". . . Retrieved 2019/03/09.