4H-Pyran-4-one, 2-(4-chlorophenyl)-2,3-dihydro-, (2R)-

Base Information

Chemical Name:4H-Pyran-4-one, 2-(4-chlorophenyl)-2,3-dihydro-, (2R)-
CAS No.:335609-84-2
Molecular Formula:C11H9ClO2
Molecular Weight:208.644
Hs Code.:
DSSTox Substance ID:DTXSID50450899
Nikkaji Number:J1.672.234K

Synonyms:335609-84-2;4H-Pyran-4-one, 2-(4-chlorophenyl)-2,3-dihydro-, (2R)-;DTXSID50450899;2beta-(4-Chlorophenyl)-2,3-dihydro-4H-pyran-4-one

Suppliers and Price of 4H-Pyran-4-one, 2-(4-chlorophenyl)-2,3-dihydro-, (2R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 4H-Pyran-4-one, 2-(4-chlorophenyl)-2,3-dihydro-, (2R)-

Chemical Property:

XLogP3:2.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:208.0291072
Heavy Atom Count:14
Complexity:242

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(OC=CC1=O)C2=CC=C(C=C2)Cl
Isomeric SMILES:C1[C@@H](OC=CC1=O)C2=CC=C(C=C2)Cl

Technology Process of 4H-Pyran-4-one, 2-(4-chlorophenyl)-2,3-dihydro-, (2R)-

There total 6 articles about 4H-Pyran-4-one, 2-(4-chlorophenyl)-2,3-dihydro-, (2R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 54125-02-9
danishefsky's diene

: 104-88-1
4-chlorobenzaldehyde

: 335609-84-2
(R)-2-(4-chlorophenyl)-2,3-dihydro-4H-pyran-4-one

Guidance literature:: With diethylzinc; (1R,2R)-bis((2,6-dichlorobenzylidene)diamino)cyclohexane; (R)-3,3'-dibromo-1,1'-bi-2-naphthol; In hexane; toluene; at -20 ℃; for 24h;
DOI:10.1016/j.tet.2005.08.007

Reference yield:

: 104-88-1
4-chlorobenzaldehyde

: (E)-1-tert-butoxy-3-ethyldimethylsiloxy-1,3-butadiene

: 335609-84-2
(R)-2-(4-chlorophenyl)-2,3-dihydro-4H-pyran-4-one

: 244614-13-9
(S)-2-(4-chlorophenyl)-2,3-dihydro-4H-pyran-4-one

Guidance literature:: 4-chlorobenzaldehyde; (E)-1-tert-butoxy-3-ethyldimethylsiloxy-1,3-butadiene; With propan-1-ol; zirconium(IV) tert-butoxide; (R)-3,3'-diiodo-2,2'-dihydroxy-1,1'-binaphthyl; water; In toluene; at -20 ℃; for 18h;

With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 1h; Title compound not separated from byproducts;
DOI:10.1021/ja028186k

Reference yield:

: 54125-02-9
danishefsky's diene

: 104-88-1
4-chlorobenzaldehyde

: 335609-84-2
(R)-2-(4-chlorophenyl)-2,3-dihydro-4H-pyran-4-one

: 244614-13-9
(S)-2-(4-chlorophenyl)-2,3-dihydro-4H-pyran-4-one

Guidance literature:: With 2,6-dimethylpyridine; ytterbium tris<(R)-(-)-1,1'-binaphthyl-2,2'-diyl phosphate>; In dichloromethane; for 16h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; Ambient temperature;
DOI:10.1055/s-1997-718