(6R-trans)-3-[(Carbamoyloxy)methyl]-8-oxo-7-(2-thienylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Base Information

Chemical Name:(6R-trans)-3-[(Carbamoyloxy)methyl]-8-oxo-7-(2-thienylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
CAS No.:37051-05-1
Molecular Formula:C15H15 N3 O6 S2
Molecular Weight:397.433
Hs Code.:
European Community (EC) Number:253-324-1
Mol file:37051-05-1.mol

Synonyms:(6R-TRANS)-3-[(CARBAMOYLOXY)METHYL]-8-OXO-7-(2-THIENYLACETAMIDO)-5-THIA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACID;NS00030148;NS00089147

Suppliers and Price of (6R-trans)-3-[(Carbamoyloxy)methyl]-8-oxo-7-(2-thienylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 6 raw suppliers

Chemical Property of (6R-trans)-3-[(Carbamoyloxy)methyl]-8-oxo-7-(2-thienylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Chemical Property:

Vapor Pressure:2.95E-31mmHg at 25°C
Boiling Point:856.6°Cat760mmHg
Flash Point:471.9°C
PSA：197.05000
Density:1.65g/cm³
LogP:1.41650
XLogP3:-1
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:7
Exact Mass:397.04022755
Heavy Atom Count:26
Complexity:682

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(=C(N2C(S1)C(C2=O)NC(=O)CC3=CC=CS3)C(=O)O)COC(=O)N
Uses Cephalosporin 87/359 is an impurity of Cefoxitin (C243190). Cefoxitin is a semi-synthetic antibiotic derived from Cephamycin C, possessing high resistance to β-lactamase inactivation. An antibacterial.

Technology Process of (6R-trans)-3-[(Carbamoyloxy)methyl]-8-oxo-7-(2-thienylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

There total 4 articles about (6R-trans)-3-[(Carbamoyloxy)methyl]-8-oxo-7-(2-thienylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.26%

: 1189-71-5
isocyanate de chlorosulfonyle

: C₁₄H₁₄N₂O₅S₂*C₁₆H₂₀N₂

: 37051-05-1,51014-46-1
(6R)-3-carbamoyloxymethyl-8-oxo-7t-(2-thiophen-2-yl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Guidance literature:: In acetone; at -55 ℃; for 2.5h;

Reference yield:

: 957-68-6
7-Aminocephalosporanic acid

: 37051-05-1,51014-46-1
(6R)-3-carbamoyloxymethyl-8-oxo-7t-(2-thiophen-2-yl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonium hydroxide / water / 1 h / 25 °C / pH 7.5

2.1: ethyl acetate / 1 h / Heating

2.2: 3 h

3.1: acetone / 2.5 h / -55 °C

With ammonium hydroxide; In water; ethyl acetate; acetone;

Reference yield:

: 15690-38-7
(6R,7R)-7-amino-3-hydroxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

: 37051-05-1,51014-46-1
(6R)-3-carbamoyloxymethyl-8-oxo-7t-(2-thiophen-2-yl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: ethyl acetate / 1 h / Heating

1.2: 3 h

2.1: acetone / 2.5 h / -55 °C

In ethyl acetate; acetone;