p-Tolylphosphoramidic dichloride

Base Information

• Chemical Name: p-Tolylphosphoramidic dichloride
• CAS No.: 33862-27-0
• Molecular Formula: C7H8Cl2NOP
• Molecular Weight: 224.026
• DSSTox Substance ID: DTXSID20565742
• Nikkaji Number: J893.211E
• Wikidata: Q82450989
• Mol file: 33862-27-0.mol

Synonyms:p-Tolylphosphoramidic dichloride;33862-27-0;SCHEMBL23133121;DTXSID20565742;N-(4-Methylphenyl)phosphoramidic dichloride

Chemical Property of p-Tolylphosphoramidic dichloride

Chemical Property:

• XLogP3: 3.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 222.9720563
• Heavy Atom Count: 12
• Complexity: 186

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)NP(=O)(Cl)Cl

Technology Process of p-Tolylphosphoramidic dichloride

There total 4 articles about p-Tolylphosphoramidic dichloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

p-toluidine (106-49-0,12221-03-3) → N-(4-methylphenyl) phosphoramidic dichloride (33862-27-0)

Guidance literature:

With triethylamine; trichlorophosphate; In acetonitrile; at -10 ℃; for 0.5h;

DOI:10.1002/mrc.928

Reference yield:

p-toluidine hydrochloride (540-23-8) → N-(4-methylphenyl) phosphoramidic dichloride (33862-27-0)

Guidance literature:

With trichlorophosphate; benzene;

Reference yield:

p-toluidine hydrochloride (540-23-8) + trichlorophosphate (10025-87-3,12599-09-6,63736-95-8,39380-77-3) → N-(4-methylphenyl) phosphoramidic dichloride (33862-27-0)

Guidance literature:

upstream raw materials:

p-toluidine hydrochloride

p-toluidine

trichlorophosphate

Downstream raw materials:

N-4-methylphenyl-N',N''-bis(piperidinyl)phosphoric triamide

(2-oxo-2λ⁵-[1,3,2]diazaphosphinan-2-yl)-p-tolyl-amine

[1,3-bis-(4-chloro-benzyl)-2-oxo-2λ⁵-[1,3,2]diazaphosphinan-2-yl]-p-tolyl-amine

diphenyl (p-tolyl)phosphoramidate