Alanine, N-(3-hydroxy-2,2-dimethyl-1-oxopropyl)-2-methyl-

Base Information

• Chemical Name: Alanine, N-(3-hydroxy-2,2-dimethyl-1-oxopropyl)-2-methyl-
• CAS No.: 339315-18-3
• Molecular Formula: C9H17NO4
• Molecular Weight: 203.23600
• Hs Code.: 2924199090
• Mol file: 339315-18-3.mol

Synonyms:2-[(3-hydroxy-2,2-dimethylpropanoyl)amino]-2-methylpropanoic acid;

Chemical Property of Alanine, N-(3-hydroxy-2,2-dimethyl-1-oxopropyl)-2-methyl-

Chemical Property:

• PSA: 86.63000
• LogP: 0.37520

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Alanine, N-(3-hydroxy-2,2-dimethyl-1-oxopropyl)-2-methyl-

There total 2 articles about Alanine, N-(3-hydroxy-2,2-dimethyl-1-oxopropyl)-2-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

3-hydroxy-2,2-dimethyl-N-[1-methyl-1-(N-methyl-N-phenylcarbamoyl)ethyl]propanamide (339315-16-1) → 2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)amino]-2-methylpropanoic acid (339315-18-3)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; at 20 ℃; for 8h;

DOI:10.1002/hlca.200390262

Reference yield:

3-Hydroxy-2,2-dimethylpropanoic acid (4835-90-9) → 2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)amino]-2-methylpropanoic acid (339315-18-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / tetrahydrofuran / 24 h / 20 °C

2: 92 percent / aq. HCl / tetrahydrofuran / 8 h / 20 °C

With hydrogenchloride; In tetrahydrofuran;

DOI:10.1002/hlca.200390262

Reference yield: 90.0%

2,2-dimethyl-3-(N-methyl-N-phenylamino)-2H-azirine (75755-40-7) + 2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)amino]-2-methylpropanoic acid (339315-18-3) → 2-({2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)amino]-2-methyl-1-oxo-propyl}amino)-N,2-dimethyl-N-phenylpropanamide (339315-20-7)

Guidance literature:

In acetonitrile; at 20 ℃; for 19h;

DOI:10.1016/S0040-4020(01)00091-6

upstream raw materials:

3-hydroxy-2,2-dimethyl-N-[1-methyl-1-(N-methyl-N-phenylcarbamoyl)ethyl]propanamide

3-Hydroxy-2,2-dimethylpropanoic acid

Downstream raw materials:

2-({2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)amino]-2-methyl-1-oxo-propyl}amino)-N,2-dimethyl-N-phenylpropanamide

2-benzyl-2-{[-({2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)amino]-2-methyl-1-oxopropyl}amino)-2-methyl-1-oxopropyl]amino}propanoic acid

2-{[2-({2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)amino]-2-methyl-1-oxo-propyl}amino)-2-methyl-1-oxopropyl]amino}-N,2-dimethyl-N-phenylpropanamide

2-benzyl-2-{[2-({2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)amino]-2-methyl-1-oxopropyl}amino)-2-methyl-1-oxopropyl]amino}-N,N-dimethylpropanamide