2-({2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)amino]-2-methyl-1-oxo-propyl}amino)-N,2-dimethyl-N-phenylpropanamide

Base Information

• Chemical Name: 2-({2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)amino]-2-methyl-1-oxo-propyl}amino)-N,2-dimethyl-N-phenylpropanamide
• CAS No.: 339315-20-7
• Molecular Formula: C₂₀H₃₁N₃O₄
• Molecular Weight: 377.484
• Mol file: 339315-20-7.mol

Synonyms:2-({2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)amino]-2-methyl-1-oxo-propyl}amino)-N,2-dimethyl-N-phenylpropanamide

Chemical Property of 2-({2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)amino]-2-methyl-1-oxo-propyl}amino)-N,2-dimethyl-N-phenylpropanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-({2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)amino]-2-methyl-1-oxo-propyl}amino)-N,2-dimethyl-N-phenylpropanamide

There total 3 articles about 2-({2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)amino]-2-methyl-1-oxo-propyl}amino)-N,2-dimethyl-N-phenylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2,2-dimethyl-3-(N-methyl-N-phenylamino)-2H-azirine (75755-40-7) + 2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)amino]-2-methylpropanoic acid (339315-18-3) → 2-({2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)amino]-2-methyl-1-oxo-propyl}amino)-N,2-dimethyl-N-phenylpropanamide (339315-20-7)

Guidance literature:

In acetonitrile; at 20 ℃; for 19h;

DOI:10.1016/S0040-4020(01)00091-6

Reference yield:

3-Hydroxy-2,2-dimethylpropanoic acid (4835-90-9) → 2-({2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)amino]-2-methyl-1-oxo-propyl}amino)-N,2-dimethyl-N-phenylpropanamide (339315-20-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 93 percent / acetonitrile / 17 h / 20 °C

2: 36 percent / 3N HCl / tetrahydrofuran / 23 h / 20 °C

3: 90 percent / acetonitrile / 19 h / 20 °C

With hydrogenchloride; In tetrahydrofuran; acetonitrile;

DOI:10.1016/S0040-4020(01)00091-6

Reference yield:

3-hydroxy-2,2-dimethyl-N-[1-methyl-1-(N-methyl-N-phenylcarbamoyl)ethyl]propanamide (339315-16-1) → 2-({2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)amino]-2-methyl-1-oxo-propyl}amino)-N,2-dimethyl-N-phenylpropanamide (339315-20-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 36 percent / 3N HCl / tetrahydrofuran / 23 h / 20 °C

2: 90 percent / acetonitrile / 19 h / 20 °C

With hydrogenchloride; In tetrahydrofuran; acetonitrile;

DOI:10.1016/S0040-4020(01)00091-6

upstream raw materials:

2,2-dimethyl-3-(N-methyl-N-phenylamino)-2H-azirine

2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)amino]-2-methylpropanoic acid

3-Hydroxy-2,2-dimethylpropanoic acid

3-hydroxy-2,2-dimethyl-N-[1-methyl-1-(N-methyl-N-phenylcarbamoyl)ethyl]propanamide

Downstream raw materials:

2-[(2-benzyl-2-({2-({2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)amino]-2-methyl-1-oxopropyl}amino)-2-methyl-1-oxopropyl}amino)-1-oxopropyl)amino]-2,N,N-trimethylpropanamide

2-benzyl-2-[(2-{[2-({2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)amino]-2-methyl-1-oxo-propyl}amino)-2-methyl-1-oxopropyl]amino}-2-methyl-1-oxopropyl)amino]-N,N-dimethylpropanamide

2-benzyl-2-{[2-({2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)amino]-2-methyl-1-oxopropyl}amino)-2-methyl-1-oxopropyl]amino}-N,N-dimethylpropanamide

2-{[2-({2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)amino]-2-methyl-1-oxo-propyl}amino)-2-methyl-1-oxopropyl]amino}-N,2-dimethyl-N-phenylpropanamide