ethyl cyano(cyclohexyl)acetate

Base Information

• Chemical Name: ethyl cyano(cyclohexyl)acetate
• CAS No.: 3213-50-1
• Molecular Formula: C11H17NO2
• Molecular Weight: 195.261
• Mol file: 3213-50-1.mol

Synonyms:NSC44911;Ethyl cyano(cyclohexyl)acetate;α-Cyanocyclohexaneacetic acid ethyl ester;Ethyl 2-cyano-2-cyclohexylacetate;AC1L63GM;AC1Q63PU;AR-1I9681;CID239612;

Chemical Property of ethyl cyano(cyclohexyl)acetate

Chemical Property:

• Vapor Pressure: 0.000713mmHg at 25°C
• Refractive Index: 1.469
• Boiling Point: 307.7 °C at 760 mmHg
• Flash Point: 142.9 °C
• Density: 1.036 g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl cyano(cyclohexyl)acetate

There total 11 articles about ethyl cyano(cyclohexyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) + ethyl 2-cyanoacetate (105-56-6) → cyano(cyclohexyl)acetic acid ethyl ester (3213-50-1)

Guidance literature:

With diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; L-proline; In ethanol; at 25 ℃; for 36h;

DOI:10.1039/b602696f

Reference yield: 92.0%

ethyl 2-cyano-2-cyclohexylideneacetate (6802-76-2) → cyano(cyclohexyl)acetic acid ethyl ester (3213-50-1)

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 0 ℃; for 0.25h;

DOI:10.1021/jacs.0c03184

Reference yield: 81.0%

ethyl 2-cyanoacetate (105-56-6) + cyclohexene (110-83-8) → cyano(cyclohexyl)acetic acid ethyl ester (3213-50-1)

Guidance literature:

With oxygen; potassium acetate; acetic acid; cobalt(II) acetate; manganese(II) acetate; at 25 ℃; for 15h;

DOI:10.1246/bcsj.78.1673

upstream raw materials:

cyclohexyl chloride

sodium cyanoacetic acid ethyl ester

Cyclohexyl iodide

ethyl 2-cyano-2-cyclohexylideneacetate

Downstream raw materials:

α-Cyclohexyl-α-isopropyl-cyanessigsaeure-ethylester

ethyl 2-cyano-2-cyclohexyl-2-phenylacetate

Propyl-cyclohexyl-malonamidsaeure

Isopropyl-cyclohexyl-malonamidsaeure