4-[(4-methoxyphenyl)methoxy]butanoic Acid

Base Information

• Chemical Name: 4-[(4-methoxyphenyl)methoxy]butanoic Acid
• CAS No.: 342893-41-8
• Molecular Formula: C12H16O4
• Molecular Weight: 224.257
• DSSTox Substance ID: DTXSID40461631
• Nikkaji Number: J2.941.015A
• Wikidata: Q82286007
• Mol file: 342893-41-8.mol

Synonyms:4-[(4-methoxyphenyl)methoxy]butanoic Acid;342893-41-8;DTXSID40461631;AKOS000246785;EN300-120288;A1-05533;Z335080100

Chemical Property of 4-[(4-methoxyphenyl)methoxy]butanoic Acid

Chemical Property:

• PSA: 55.76000
• LogP: 2.07660
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 7
• Exact Mass: 224.10485899
• Heavy Atom Count: 16
• Complexity: 197

Purity/Quality:

99% ^*data from raw suppliers

4-[(4-Methoxyphenyl)methoxy]butanoic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)COCCCC(=O)O

Technology Process of 4-[(4-methoxyphenyl)methoxy]butanoic Acid

There total 5 articles about 4-[(4-methoxyphenyl)methoxy]butanoic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-(p-methoxybenzyloxy)butan-1-ol (119649-45-5) → 4-(4-methoxy-benzyloxy)butyric acid (342893-41-8)

Guidance literature:

With jones reagent; In acetone; for 1.5h;

DOI:10.1021/ol0275264

Reference yield: 90.0%

4-((4-methoxybenzyl)oxy)butanal (119649-27-3) → 4-(4-methoxy-benzyloxy)butyric acid (342893-41-8)

Guidance literature:

With sodium chlorite; sodium dihydrogenphosphate dihydrate; In 2-methyl-but-2-ene; water; tert-butyl alcohol; at 20 ℃; for 6h;

DOI:10.1055/s-0031-1289574

Reference yield: 68.0%

4-butanolide (96-48-0) + p-methoxybenzyl chloride (824-94-2) → 4-(4-methoxy-benzyloxy)butyric acid (342893-41-8)

Guidance literature:

With potassium hydroxide; In toluene; for 48h; Reflux; Inert atmosphere;

DOI:10.1039/c3cc49205b

upstream raw materials:

4-(p-methoxybenzyloxy)butan-1-ol

p-methoxybenzyl chloride

p-Methoxybenzyl bromide

4-((4-methoxybenzyl)oxy)butanal

Downstream raw materials:

4-(4-Methoxy-benzyloxy)-butyric acid (4Z,7Z)-trideca-4,7-dienyl ester

4-(4-methoxybenzyloxy)butyric acid tert-butyl ester

(4aR,6S,7R,8S,8aR)-4-(4-methoxybenzyloxy)butyric acid 2,2-di(tert-butyl)-6-methyl-6-(2-methylallyl)-8-(trimethylsilanyloxy)-4,4a,6,7,8,8a-hexahydro-1,3,5-trioxa-2-silanaphthalen-7-yl ester

4-(4-Methoxy-benzyloxy)-butyric acid (4aR,6S,7R,8R,8aR)-2,2-di-tert-butyl-8-(tert-butyl-diphenyl-silanyloxy)-6-methyl-6-(2-methyl-allyl)-hexahydro-1,3,5-trioxa-2-sila-naphthalen-7-yl ester