(2-aminophenyl)(cyclohexyl)methanone

Base Information

• Chemical Name: (2-aminophenyl)(cyclohexyl)methanone
• CAS No.: 3432-87-9
• Molecular Formula: C13H17NO
• Molecular Weight: 203.284
• Mol file: 3432-87-9.mol

Synonyms:

Chemical Property of (2-aminophenyl)(cyclohexyl)methanone

Chemical Property:

• Vapor Pressure: 5.21E-05mmHg at 25°C

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2-aminophenyl)(cyclohexyl)methanone

There total 13 articles about (2-aminophenyl)(cyclohexyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

C18H25NO2 (1228191-29-4) → (2-aminophenyl)cyclohexylmethanone (3432-87-9)

Guidance literature:

C₁₈H₂₅NO₂; With hydrogenchloride; water; In 1,4-dioxane; at 80 ℃; Inert atmosphere;

With sodium hydrogencarbonate; In 1,4-dioxane; water; Inert atmosphere;

DOI:10.1021/ol101040p

Reference yield: 91.0%

cyclohexylmagnesiumchloride (931-51-1) + anthranilic acid (118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4) → (2-aminophenyl)cyclohexylmethanone (3432-87-9)

Guidance literature:

anthranilic acid; With tert-butylmagnesium chloride; In tetrahydrofuran; toluene; at 0 ℃; for 0.25h; Inert atmosphere;

cyclohexylmagnesiumchloride; With diisopropylaminomagnesium chloride lithium chloride; In tetrahydrofuran; diethyl ether; toluene; at 0 - 20 ℃; for 14.25h; Inert atmosphere; Sonication;

DOI:10.1021/acs.orglett.9b02899

Reference yield: 70.0%

1-bromocyclohexane (108-85-0) + anthranilic acid nitrile (1885-29-6) → (2-aminophenyl)cyclohexylmethanone (3432-87-9)

Guidance literature:

1-bromocyclohexane; With magnesium; In diethyl ether; Heating;

anthranilic acid nitrile; In diethyl ether; Heating;

With hydrogenchloride; In diethyl ether;

DOI:10.1021/jm031115r

upstream raw materials:

1-bromocyclohexane

anthranilic acid nitrile

N-(2-(cyclohexanecarbonyl)phenyl)acetamide

2-methyl-4-oxo-3,1-benzoxazine

Downstream raw materials:

cyclohexyl-[2-(N-Cbzaminomethylcarbamoyl)phenyl]ketone

(S)-2-(2-(cyclohexylcarbonyl)phenylamino)-3-<4-<2-(5-methyl-2-phenyloxazol-4-yl)ethoxy>phenyl>propionic acid methyl ester

(R)-2-(2-(cyclohexylcarbonyl)phenylamino)-3-<4-<2-(5-methyl-2-phenyloxazol-4-yl)ethoxy>phenyl>propionic acid methyl ester

2,2,2-trichloro-N-[2-(cyclohexylcarbonyl)phenyl]acetamide