2,2-Dibromo-1-(2-chlorophenyl)ethanone

Base Information

• Chemical Name: 2,2-Dibromo-1-(2-chlorophenyl)ethanone
• CAS No.: 34356-83-7
• Molecular Formula: C8H5Br2ClO
• Molecular Weight: 312.388
• UNII: 474C9TC8MZ
• Nikkaji Number: J2.878.740E
• Mol file: 34356-83-7.mol

Synonyms:2,2-dibromo-1-(2-chlorophenyl)ethanone;34356-83-7;Ethanone, 2,2-dibromo-1-(2-chlorophenyl)-;alpha,alpha-Dibromo-2'-chloroacetophenone;starbld0027413;SCHEMBL235265;474C9TC8MZ;MFCD31630601;Acetophenone, 2,2-dibromo-2'-chloro-;2,2-Dibromo-1-(2-chlorophenyl)ethanon;2'-Chloro-alpha,alpha-dibromoacetophenone;SY291367;E86478

Chemical Property of 2,2-Dibromo-1-(2-chlorophenyl)ethanone

Chemical Property:

• XLogP3: 3.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 311.83752
• Heavy Atom Count: 12
• Complexity: 172

Purity/Quality:

>95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)C(=O)C(Br)Br)Cl

Technology Process of 2,2-Dibromo-1-(2-chlorophenyl)ethanone

There total 10 articles about 2,2-Dibromo-1-(2-chlorophenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2,2,2-tribromo-1-(2-chlorophenyl)ethan-1-one → 2,2‐dibromo‐1‐(2‐chlorophenyl)ethan‐1‐one (34356-83-7)

Guidance literature:

With water; hydrogen bromide; In tetrahydrofuran; at 80 ℃;

DOI:10.1002/ejoc.202001118

Reference yield: 86.0%

2-chlorophenylacetylene (873-31-4) → 2,2‐dibromo‐1‐(2‐chlorophenyl)ethan‐1‐one (34356-83-7)

Guidance literature:

With N,N'-ethylenethiourea; 1,3-dibromo-5,5-dimethylhydantoin; water; at 20 ℃;

DOI:10.1039/c7gc00283a

Reference yield: 83.0%

2‐chloro‐N‐methoxy‐N‐methylbenzamide (289686-74-4) + 1,1-dibromomethane (74-95-3) → 2,2‐dibromo‐1‐(2‐chlorophenyl)ethan‐1‐one (34356-83-7)

Guidance literature:

With methyllithium lithium bromide; diisopropylamine; In tetrahydrofuran; at -78 ℃; for 1h; chemoselective reaction; Inert atmosphere;

DOI:10.1002/adsc.202001106

upstream raw materials:

1-(2-chlorophenyl)ethanone

2-chlorophenacyl bromide

2-chlorostyrene

2-chlorophenylacetylene

Downstream raw materials:

2-(2-chlorophenyl)-3,3-dibromoacrylonitrile

1-(2-chlorophenyl)-2-(p-tosyl)ethanone