4-(3-(Pyrrolidin-1-yl)propoxy)aniline

Base Information

Chemical Name:4-(3-(Pyrrolidin-1-yl)propoxy)aniline
CAS No.:343965-79-7
Molecular Formula:C13H20N2O
Molecular Weight:220.315
Hs Code.:
DSSTox Substance ID:DTXSID10513378
Wikidata:Q82373164

Synonyms:343965-79-7;4-(3-(Pyrrolidin-1-yl)propoxy)aniline;4-[3-(pyrrolidin-1-yl)propoxy]aniline;4-(3-pyrrolidin-1-ylpropoxy)aniline;SCHEMBL4457910;DTXSID10513378;TWOVRSMFLFYABX-UHFFFAOYSA-N;4-[3-(1-pyrrolidinyl)propoxy]aniline;EN300-52125

Suppliers and Price of 4-(3-(Pyrrolidin-1-yl)propoxy)aniline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 4-(3-(Pyrrolidin-1-yl)propoxy)aniline

Chemical Property:

XLogP3:2.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:220.157563266
Heavy Atom Count:16
Complexity:184

Purity/Quality:: 95+% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCN(C1)CCCOC2=CC=C(C=C2)N

Technology Process of 4-(3-(Pyrrolidin-1-yl)propoxy)aniline

There total 5 articles about 4-(3-(Pyrrolidin-1-yl)propoxy)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 92033-81-3
1-{3-[(4-nitrophenyl)oxy]propyl}pyrrolidine

: 343965-79-7
1-{3-[(4-aminophenyl)oxy]propyl}pyrrolidine

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 20h; under 760.051 Torr;
DOI:10.1021/jm8003834

Reference yield:

: 13094-50-3
1-(3-bromopropoxy)-4-nitrobenzene

: 343965-79-7
1-{3-[(4-aminophenyl)oxy]propyl}pyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 80 °C

2: palladium 10% on activated carbon; hydrogen / methanol

With palladium 10% on activated carbon; hydrogen; potassium carbonate; In methanol; acetonitrile;
DOI:10.1016/j.bmcl.2012.06.088

Reference yield:

: 19748-66-4
3-pyrrolidin-1-yl-propan-1-ol

: 343965-79-7
1-{3-[(4-aminophenyl)oxy]propyl}pyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / acetonitrile / 3 h / Reflux

2: palladium 10% on activated carbon; hydrogen / ethanol / 12 h / 20 °C

With palladium 10% on activated carbon; hydrogen; triethylamine; In ethanol; acetonitrile;
DOI:10.1016/j.ejmech.2019.111590