1-Pyrrolidinepropanol

Base Information

• Chemical Name: 1-Pyrrolidinepropanol
• CAS No.: 19748-66-4
• Molecular Formula: C7H15NO
• Molecular Weight: 129.202
• Hs Code.: 2933990090
• European Community (EC) Number: 801-625-9
• DSSTox Substance ID: DTXSID30173433
• Nikkaji Number: J2.529.998A
• Wikidata: Q72481505
• Mol file: 19748-66-4.mol

Synonyms:19748-66-4;1-Pyrrolidinepropanol;3-(Pyrrolidin-1-yl)propan-1-ol;3-(1-Pyrrolidyl)-1-propanol;3-pyrrolidin-1-ylpropan-1-ol;1-(3-HYDROXYPROPYL)-PYRROLIDINE;BRN 0103382;1-(3-Hydroxypropyl)pyrrolidine;gamma-Pyrrolidinopropanol [German];gamma-Pyrrolidinopropanol;3-(1-pyrrolidinyl)-1-propanol;MFCD01687769;4-20-00-00118 (Beilstein Handbook Reference);hydroxypropylpyrrolidine;1-Pyrrolidinepropanol [also: 1-(3-Hydroxypropyl)pyrrolidine];3-pyrrolidinopropan-1-ol;3-Pyrrolizino-1-propanol;SCHEMBL9129;(3-hydroxypropyl)pyrrolidine;3-pyrrolidin-1-yl-propan-1-ol;DTXSID30173433;3-pyrrolidin-1-yl-propan -1-ol;AMY38662;AKOS002682746;CS-W005320;AC-17216;DS-18271;SY024340;LS-138131;FT-0715639;EN300-80458

Chemical Property of 1-Pyrrolidinepropanol

Chemical Property:

• Vapor Pressure: 0.0293mmHg at 25°C
• Refractive Index: 1.482
• Boiling Point: 216.9 °C at 760 mmHg
• PKA: 15.02±0.10(Predicted)
• Flash Point: 97.7 °C
• PSA: 23.47000
• Density: 0.983 g/cm³
• LogP: 0.40250
• Storage Temp.: 2-8°C
• XLogP3: 0.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 129.115364102
• Heavy Atom Count: 9
• Complexity: 69.3

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-(Pyrrolidin-1-yl)propan-1-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCN(C1)CCCO

Technology Process of 1-Pyrrolidinepropanol

There total 16 articles about 1-Pyrrolidinepropanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

pyrrolidine (123-75-1) + 1-bromo-3-propanol (627-18-9) → 3-pyrrolidin-1-yl-propan-1-ol (19748-66-4)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; at 20 ℃; for 15h;

DOI:10.1021/jm8003834

Reference yield: 95.0%

methyl 3-(pyrrolidin-1-yl)propanoate (22041-21-0) → 3-pyrrolidin-1-yl-propan-1-ol (19748-66-4)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 20 ℃; for 2h;

DOI:10.1016/j.tet.2007.10.045

Reference yield: 72.0%

pyrrolidine (123-75-1) + allyl alcohol (107-18-6) → 3-pyrrolidin-1-yl-propan-1-ol (19748-66-4)

Guidance literature:

With potassium phosphate; [(bis(2-dicyclohexylphosphinoethyl)amine)Fe(CO)Br₂]; sodium triethylborohydride; In cyclohexane; at 80 ℃; for 12h; Inert atmosphere; Sealed tube;

DOI:10.1021/jacs.9b05221

upstream raw materials:

pyrrolidine

1-chloro-3-hydroxypropane

trimethyleneglycol

methyl 3-(2'-oxo-1'-pyrrolidinyl)propanoate

Downstream raw materials:

1-{3-[(4-nitrophenyl)oxy]propyl}pyrrolidine

2-[3-(1-pyrrolidinyl)propoxy]-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

7-benzyl-2-(3-pyrrolidin-1-ylpropoxy)-5,6,7,8-tetrahydro-1,7-naphthyridine

2,2-diphenyl-5-pyrrolidino-valeronitrile; hydrochloride

Refernces

• 1、 Das, Kuhali,Sarkar, Koushik,Maji, Biplab. "Manganese-Catalyzed Anti-Markovnikov Hydroamination of Allyl Alcohols via Hydrogen-Borrowing Catalysis". . p. 7060 - 7069. Retrieved 2021/06/30.
• 2、 -. "AZAINDENOISOQUINOLINE COMPOUNDS AND USES THEREOF". Paragraph 0072. . Retrieved 2018/07/29.