Hydroxy CyclophosphaMide O-MethyloxiMe

Base Information

• Chemical Name: Hydroxy CyclophosphaMide O-MethyloxiMe
• CAS No.: 343967-21-5
• Molecular Formula: C8H18Cl2N3O3P
• Molecular Weight: 306.12700
• Mol file: 343967-21-5.mol

Synonyms:Hydroxy Cyclophosphamide O-Methyloxime;aldophosphamide O-methyloxime;(Z)-aldophosphamide O-methyl oxime;

Chemical Property of Hydroxy CyclophosphaMide O-MethyloxiMe

Chemical Property:

• Melting Point: 75 - 78°C
• PSA: 86.96000
• LogP: 2.57200
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: Chloroform (Slightly), DMSO (Slightly)

Purity/Quality:

Hydroxy Cyclophosphamide O-Methyloxime ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N,N-Bis(2-chloroethyl-phosphorodiamidic Acid 3-(Methoxyimino)propyl Ester is a derivative of 4-Hydroperoxy Cyclophosphamide (H714675), a metabolite of Cyclophosphamide. Antineoplastic; bone marrow purging agent.

Technology Process of Hydroxy CyclophosphaMide O-MethyloxiMe

There total 5 articles about Hydroxy CyclophosphaMide O-MethyloxiMe which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trans-4-hydroperoxycyclophosphamide (39800-16-3,56922-83-9,61903-31-9,62435-42-1,146566-40-7) → aldophosphamide O-methyloxime (343967-21-5,82084-80-8)

Guidance literature:

Multi-step reaction with 2 steps

1: Ph₃P / 0.08 h

2: NaOH / D₂O / 0.17 h / lutidine buffer, pH 7.4

With sodium hydroxide; triphenylphosphine; In water-d2;

DOI:10.1002/jps.2600710417

Reference yield:

N-methoxylamine hydrochloride (593-56-6) + trans-4-hydroxycyclophosphamide (61903-30-8,88852-78-2,40277-05-2,61903-29-5,88852-77-1) → aldophosphamide O-methyloxime (343967-21-5,82084-80-8) + (E)-aldophosphamide O-methyl oxime (82084-80-8)

Guidance literature:

With sodium hydroxide; for 0.166667h; Title compound not separated from byproducts; lutidine buffer, pH 7.4;

DOI:10.1002/jps.2600710417

Reference yield:

N-methoxylamine hydrochloride (593-56-6) + 4-hydroperoxycyclophosphamide (39800-16-3,146566-40-7) → aldophosphamide O-methyloxime (343967-21-5,82084-80-8) + (E)-aldophosphamide O-methyl oxime (82084-80-8)

Guidance literature:

With sodium hydroxide; In water; for 24h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; Ambient temperature;

DOI:10.1002/jps.2600710417

upstream raw materials:

N-methoxylamine hydrochloride

trans-4-hydroxycyclophosphamide

4-hydroperoxycyclophosphamide

4-peroxycyclophosphamide