Methoxyammonium chloride

Base Information

• Chemical Name: Methoxyammonium chloride
• CAS No.: 593-56-6
• Molecular Formula: CH5NO^.HCl
• Molecular Weight: 83.5177
• Hs Code.: 2928 00 90
• European Community (EC) Number: 209-798-7
• Mol file: 593-56-6.mol

Synonyms:Methoxyammonium chloride;O-methylhydroxylammonium chloride;methoxyamine.hcl;O-methylhydroxyammonium chloride;SPUACDWLOLSOQO-UHFFFAOYSA-M;0-methylhydroxylamine hydrochloride;AKOS015833227;LS-1418

Chemical Property of Methoxyammonium chloride

Chemical Property:

• Appearance/Colour: White to very faintly yellow crystalline powder
• Vapor Pressure: 298mmHg at 25°C
• Melting Point: 151-154 °C(lit.)
• Refractive Index: n20/D 1.4021
• Boiling Point: 49.5 °C at 760 mmHg
• Flash Point: 18.2 °C
• PSA: 35.25000
• Density: 0.854 g/cm³
• LogP: 1.00880
• Storage Temp.: Store below +30°C.
• Sensitive.: Hygroscopic
• Solubility.: alcohol: soluble(lit.)
• Water Solubility.: SOLUBLE
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 83.0137915
• Heavy Atom Count: 4
• Complexity: 4.8

Purity/Quality:

99% ^*data from raw suppliers

o-Methylhydroxylamine HCl ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C,Xi,N
• Hazard Codes: C,Xi,N
• Statements: 34-36/37/38-50-43-20/21/22-37-35
• Safety Statements: 3-24-26-36/37/39-45-61-24/25-27

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CO[NH3+].[Cl-]
• Uses: antineoplastic, hydroxymethyltransferase inhibitor Methoxylamine is a methoxime derivative used as internal standard for Prostaglandin assays by gas chromatography-mass spectrometry Methoxylamine hydrochloride is used as a reagent in the preparation of O-methyl oximes from aldehydes. It is orally bioavailable small molecule inhibitor with potential adjuvant activity. It is also used as internal standard for prostaglandin assays by gas chromatography-mass spectrometry.

Technology Process of Methoxyammonium chloride

There total 24 articles about Methoxyammonium chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.3%

acetylhydroxamic acid (546-88-3) + dimethyl sulfate (77-78-1) → N-methoxylamine hydrochloride (593-56-6)

Guidance literature:

acetylhydroxamic acid; dimethyl sulfate; With sodium hydrogencarbonate; sodium hydroxide; In water; at 20 ℃; for 3.5h; pH=7.5 - 8;

With hydrogenchloride; In water; isopropyl alcohol; at 20 ℃; for 0.5h; pH=< 2; Temperature; pH-value;

Reference yield: 96.22%

3-methoxy-4-hydroxybenzaldehyde methyl oxime → N-methoxylamine hydrochloride (593-56-6) + (E)-4-hydroxy-3-methoxybenzaldehyde oxime (134283-49-1)

Guidance literature:

With hydroxylamine hydrochloride; In methanol; water; at 40 ℃;

Reference yield: 90.0%

N-methoxyphthalimide (1914-20-1) → N-methoxylamine hydrochloride (593-56-6)

Guidance literature:

N-methoxyphthalimide; With methylhydrazine; In dichloromethane; at 0 - 20 ℃; for 2h;

With hydrogenchloride; In 1,4-dioxane; at 0 ℃;

upstream raw materials:

N-methoxybenzamide

hydrogenchloride

(MeON=C(Me)-CMe=NOMe)

N-methoxyphthalimide

Downstream raw materials:

hydroxy-methoxyamino-malonic acid amide-p-toluidide

hydroxy-methoxyamino-malonic acid di-p-toluidide

2-isopropyl-5-methyl-[1,4]benzoquinone-4-(O-methyl oxime )

3-amino-2-hydroxy-benzaldehyde-(O-methyl oxime )

Refernces

• 1、 -. "Preparation method of methoxyamine hydrochloride and preparation method of N-methoxyacetamide". Paragraph 0038-0052. . Retrieved 2021/05/29.
• 2、 -. "Preparation method O - alkyl substituted hydroxylamine salt". Paragraph 0088-0091. . Retrieved 2021/11/14.