L-SEPIAPTERIN

Base Information

• Chemical Name: L-SEPIAPTERIN
• CAS No.: 17094-01-8
• Molecular Formula: C9H11 N5 O3
• Molecular Weight: 237.218
• Hs Code.: 2933990090
• Mol file: 17094-01-8.mol

Synonyms:1-Propanone,1-(2-amino-7,8-dihydro-4-hydroxy-6-pteridinyl)-2-hydroxy- (6CI,7CI,8CI); 4(1H)-Pteridinone,2-amino-7,8-dihydro-6-(2-hydroxy-1-oxopropyl)-, (S)-; 4(1H)-Pteridinone,2-amino-7,8-dihydro-6-[(2S)-2-hydroxy-1-oxopropyl]- (9CI); L-Sepiapterin;Sepiapterin; Sepiapterine

Chemical Property of L-SEPIAPTERIN

Chemical Property:

• Appearance/Colour: Yellow Solid
• Vapor Pressure: 6.54E-10mmHg at 25°C
• Boiling Point: 448.1 °C at 760 mmHg
• PKA: 12.33±0.20(Predicted)
• Flash Point: 224.8 °C
• PSA: 133.46000
• Density: 1.86 g/cm³
• LogP: -1.04520
• Storage Temp.: −20°C
• Solubility.: DMSO: 27 mg/mL

Purity/Quality:

98%,99%, ^*data from raw suppliers

L-Sepiapterin ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

Total 1 MSDS from other Authors

Useful:

• Uses: L-Sepiapterin serves as a substrate for BH4 synthesis via the pterin salvage pathway. It inhibits rat liver GTP cyclohydrolase with an IC50 value of approximately 25 μM. It can be used to circumvent the inhibition of pterin biosynthesis by 2,4-diamino-6-hydroxy pyrimidine.[Cayman Chemical] Sepiapterin improved the endothelial dysfunction in SMA from db?/db mice by decreasing oxidative stress. Sepiapterin is commonly used in the study for treamtment of Type I Diabetes Sepiapterin can be used to induce sequence-specific photolesions in double-stranded DNA.

Technology Process of L-SEPIAPTERIN

There total 9 articles about L-SEPIAPTERIN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-amino-6-(2S-2-hydroxypropionyl)-5,6,7,8-tetrahydro-3H-pteridin-4-one dihydrochloride → sepiapterin (17094-01-8)

Guidance literature:

With dihydrogen peroxide; In ethanol; water; at -10 ℃; for 2h; Reagent/catalyst; Temperature; Solvent;

Reference yield: 88.0%

1-[4-tert-butoxycarbonyloxy-2-(N,N-di-tert-butoxycarbonyl)amino-7,8-dihydropteridin-6-yl]-2S-2-(tert-butyldimethylsilanyloxy)propan-1-one → sepiapterin (17094-01-8)

Guidance literature:

1-[4-tert-butoxycarbonyloxy-2-(N,N-di-tert-butoxycarbonyl)amino-7,8-dihydropteridin-6-yl]-2S-2-(tert-butyldimethylsilanyloxy)propan-1-one; With hydrogenchloride; In water; acetonitrile; at 50 ℃; for 3h;

With sodium hydroxide; In water; acetonitrile; pH=7;

Reference yield: 86.0%

1-(2-amino-4-cyclohexyloxy-7,8-dihydropteridin-6-yl)-2S-2-(methoxyethoxymethoxy)propan-1-one → sepiapterin (17094-01-8)

Guidance literature:

1-(2-amino-4-cyclohexyloxy-7,8-dihydropteridin-6-yl)-2S-2-(methoxyethoxymethoxy)propan-1-one; With hydrogenchloride; ascorbic acid; In methanol; water; at 50 ℃; for 6h; Darkness;

With ammonia; In methanol; water; pH=7;

upstream raw materials:

1-(2-amino-4-cyclohexyloxypteridin-6-yl)-1R,2S-1-hydroxy-2-(methoxymethoxy)propan

Downstream raw materials:

2,5-dihydroxybenzoic acid.