Technology Process of 1-(2-amino-4-cyclohexyloxypteridin-6-yl)-1R,2S-1-hydroxy-2-(methoxymethoxy)propan
There total 1 articles about 1-(2-amino-4-cyclohexyloxypteridin-6-yl)-1R,2S-1-hydroxy-2-(methoxymethoxy)propan which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2,6-diamino-4-(cyclohexyloxy)-5-nitrosopyrimidine;
With
5%-palladium/activated carbon; hydrogen;
In
acetonitrile;
at 20 ℃;
(4S)-2,3-epoxy-4-(methoxymethoxy)pentanal;
With
hydrogenchloride;
In
water; acetonitrile;
for 1h;
With
dihydrogen peroxide; iodine;
In
water; acetonitrile;
for 12h;
regioselective reaction;
DOI:10.3987/COM-08-S(N)99
- Guidance literature:
-
With
hydrogenchloride;
In
methanol; water;
at 50 ℃;
for 23h;
DOI:10.3987/COM-08-S(N)99
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / acetonitrile / 1 h / 60 °C / Inert atmosphere; Molecular sieve
2.1: hydrogenchloride / methanol; water / 3 h / 50 °C
2.2: pH 7
3.1: hydrogen; Pd/C (Ph2S); triethylamine / methanol; water / 3 h / 40 °C
With
hydrogenchloride; tetrapropylammonium perruthennate; Pd/C (Ph2S); hydrogen; 4-methylmorpholine N-oxide; triethylamine;
In
methanol; water; acetonitrile;
