Technology Process of Benzaldehyde, 3-[6-[1-methyl-1-(methylsulfonyl)ethyl]-8-quinolinyl]-
There total 8 articles about Benzaldehyde, 3-[6-[1-methyl-1-(methylsulfonyl)ethyl]-8-quinolinyl]- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium carbonate;
palladium on activated charcoal;
In
water; N,N-dimethyl-formamide;
at 80 ℃;
Further Variations:;
Catalysts;
Reagents;
Product distribution;
Kinetics;
DOI:10.1002/adsc.200303036
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium 3-nitrobenzenesulfonate; ferrous(II) sulfate heptahydrate / methanesulfonic acid / 118 - 125 °C / Large scale
1.2: 125 - 133 °C / Large scale
2.1: 2,2'-azobis-(2,4-dimethylvaleronitrile); N-Bromosuccinimide / chlorobenzene / 19 h / 48 - 52 °C / Inert atmosphere; Large scale
3.1: N,N-dimethyl-formamide / 3 h / 13 - 17 °C / Large scale
3.2: 1 h / 75 - 80 °C / Large scale
4.1: sodium t-butanolate / N,N-dimethyl-formamide
5.1: sodium t-butanolate / N,N-dimethyl-formamide
6.1: potassium carbonate; 5%-palladium/activated carbon / N,N-dimethyl-formamide; water / 2 h / 0.8 °C / Inert atmosphere; Large scale
With
ferrous(II) sulfate heptahydrate; N-Bromosuccinimide; 2,2'-azobis-(2,4-dimethylvaleronitrile); 5%-palladium/activated carbon; potassium carbonate; sodium 3-nitrobenzenesulfonate; sodium t-butanolate;
In
methanesulfonic acid; water; N,N-dimethyl-formamide; chlorobenzene;
1.1: |Skraup Quinoline Synthesis / 1.2: |Skraup Quinoline Synthesis / 6.1: |Suzuki-Miyaura Coupling;
DOI:10.1021/op050116l
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 2,2'-azobis-(2,4-dimethylvaleronitrile); N-Bromosuccinimide / chlorobenzene / 19 h / 48 - 52 °C / Inert atmosphere; Large scale
2.1: N,N-dimethyl-formamide / 3 h / 13 - 17 °C / Large scale
2.2: 1 h / 75 - 80 °C / Large scale
3.1: sodium t-butanolate / N,N-dimethyl-formamide
4.1: sodium t-butanolate / N,N-dimethyl-formamide
5.1: potassium carbonate; 5%-palladium/activated carbon / N,N-dimethyl-formamide; water / 2 h / 0.8 °C / Inert atmosphere; Large scale
With
N-Bromosuccinimide; 2,2'-azobis-(2,4-dimethylvaleronitrile); 5%-palladium/activated carbon; potassium carbonate; sodium t-butanolate;
In
water; N,N-dimethyl-formamide; chlorobenzene;
5.1: |Suzuki-Miyaura Coupling;
DOI:10.1021/op050116l
