2,3-Dimethyl-5-methoxyphenol

Base Information

• Chemical Name: 2,3-Dimethyl-5-methoxyphenol
• CAS No.: 34883-01-7
• Molecular Formula: C9H12O2
• Molecular Weight: 152.19000
• Hs Code.: 2909500000
• Mol file: 34883-01-7.mol

Synonyms:1-Hydroxy-3-methoxy-5,6-dimethylbenzol;5-Methoxy-2,3-dimethyl-phenol;2,3-Dimethyl-5-methoxyphenol;Phenol,5-methoxy-2,3-dimethyl;3-Hydroxy-5-methoxy-1,2-xylene;3-Hydroxy-5-methoxy-1,2-dimethylbenzol;

Chemical Property of 2,3-Dimethyl-5-methoxyphenol

Chemical Property:

• PSA: 29.46000
• LogP: 2.01760

Purity/Quality:

95% ^*data from raw suppliers

5-Methoxy-2,3-dimethylphenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Methoxy-2,3-dimethylphenol can be as potential coffee beans’ markers.

Technology Process of 2,3-Dimethyl-5-methoxyphenol

There total 4 articles about 2,3-Dimethyl-5-methoxyphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-bromo-3-methoxy-5,6-dimethylcyclohex-2-en-1-one → 2,3-Dimethyl-5-methoxyphenol (34883-01-7)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In toluene;

DOI:10.1021/acs.joc.5b00192

Reference yield: 17.0%

3-methoxy-5,5-dimethyl-cyclohex-2-enone (4683-45-8) → 2,3-Dimethyl-5-methoxyphenol (34883-01-7) + 4,5-Dimethyl-3-methoxyphenol (146335-37-7)

Guidance literature:

With sulfuric acid; trifluoroacetic anhydride; for 20h; Ambient temperature;

DOI:10.1055/s-1992-26360

Reference yield:

2,4-dihydroxy-6-methylbenzaldehyde (487-69-4) → 2,3-Dimethyl-5-methoxyphenol (34883-01-7)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) K₂CO₃, acetone, (ii) Na2(OCH₂CH₂OMe)2>

2: H₂ / PdO

With hydrogen; trimethyleneglycol;

upstream raw materials:

diazomethane

4,5-dimethylresorcinol

3-methoxy-5,5-dimethyl-cyclohex-2-enone

2,4-dihydroxy-6-methylbenzaldehyde

Downstream raw materials:

1-Hydroxy-3-methoxy-4,5,6-trimethylbenzol