2-(Tritylthio)acetic acid

Base Information

• Chemical Name: 2-(Tritylthio)acetic acid
• CAS No.: 34914-36-8
• Molecular Formula: C21H18O2S
• Molecular Weight: 334.439
• DSSTox Substance ID: DTXSID90401163
• Nikkaji Number: J1.697.874D
• Wikidata: Q82204215
• Mol file: 34914-36-8.mol

Synonyms:2-(tritylthio)acetic acid;34914-36-8;2-tritylsulfanylacetic Acid;Acetic acid, [(triphenylmethyl)thio]-;S-Trityl-mercaptoacetic acid;MFCD00386069;2-(triphenylmethylthio)acetic acid;2-(tritylthio)aceticacid;S-Trityl Mercaptoacetic Acid;SCHEMBL342181;DTXSID90401163;RYRPHZROJNDXEV-UHFFFAOYSA-N;2-(triphenylmethylthio)ethanoic Acid;s-triphenylmethyl-mercaptoacetic acid;AKOS024355933;BS-16933;SY288205;CS-0161576;D82151

Chemical Property of 2-(Tritylthio)acetic acid

Chemical Property:

• XLogP3: 5.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 6
• Exact Mass: 334.10275099
• Heavy Atom Count: 24
• Complexity: 345

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3)SCC(=O)O

Technology Process of 2-(Tritylthio)acetic acid

There total 12 articles about 2-(Tritylthio)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

triphenylmethyl thioglycolic acid methyl ester (83544-05-2) → 2-(triphenylmethylthio)ethanoic acid (34914-36-8)

Guidance literature:

triphenylmethyl thioglycolic acid methyl ester; With potassium hydroxide; In methanol;

With hydrogenchloride; In ethanol; water; pH=6;

Reference yield: 99.0%

triphenylmethanethiol (3695-77-0) + bromoacetic acid (79-08-3) → 2-(triphenylmethylthio)ethanoic acid (34914-36-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

DOI:10.1021/ol203259a

Reference yield: 95.0%

trityl chloride (76-83-5) + mercaptoacetic acid (68-11-1) → 2-(triphenylmethylthio)ethanoic acid (34914-36-8)

Guidance literature:

In dichloromethane;

upstream raw materials:

sodium monochloroacetic acid

trityl chloride

mercaptoacetic acid

Triphenylmethylethylether

Downstream raw materials:

C₄₇H₃₉NO₈S

2-(triphenylmethylthio)ethanoic acid-N-hydroxysuccinimido ester

N-(S-trityl-2-mercaptoacetyl)-3-aminopropanol

N-phenyl-2-tritylsulfanyl-acetamide