Cyclohexanone, 2-[(R)-hydroxy(4-nitrophenyl)methyl]-, (2R)-

Base Information

• Chemical Name: Cyclohexanone, 2-[(R)-hydroxy(4-nitrophenyl)methyl]-, (2R)-
• CAS No.: 349628-69-9
• Molecular Formula: C13H15NO4
• Molecular Weight: 249.266
• Mol file: 349628-69-9.mol

Synonyms:

Chemical Property of Cyclohexanone, 2-[(R)-hydroxy(4-nitrophenyl)methyl]-, (2R)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cyclohexanone, 2-[(R)-hydroxy(4-nitrophenyl)methyl]-, (2R)-

There total 30 articles about Cyclohexanone, 2-[(R)-hydroxy(4-nitrophenyl)methyl]-, (2R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) + 4-nitrobenzaldehdye (555-16-8) → (2R)-2-[(R)-hydroxy(4-nitrophenyl)methyl]cyclohexanone (349628-69-9)

Guidance literature:

With Br^(1-)*C₁₃H₂₆NO₂⁽¹⁺⁾; L-proline; In water; dimethyl sulfoxide; at 20 ℃; for 24h; optical yield given as %ee; diastereoselective reaction;

DOI:10.1590/S0103-50532011000900016

Reference yield: 88.0%

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) + 4-nitrobenzaldehdye (555-16-8) → (2R)-2-[(S)-hydroxy(4-nitrophenyl)methyl]cyclohexanone (351533-35-2,501417-31-8) + (2R)-2-[(R)-hydroxy(4-nitrophenyl)methyl]cyclohexanone (349628-69-9)

Guidance literature:

With water; benzoic acid; In neat (no solvent); at 25 ℃; for 24h; enantioselective reaction; Inert atmosphere;

DOI:10.1002/hlca.201200422 DOI:10.1002/hlca.201200422

Reference yield: 86.0%

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) + 4-nitrobenzaldehdye (555-16-8) → 2-(hydroxy-(p-nitrophenyl)methyl)cyclohexan-1-one (61235-16-3) + (2R)-2-[(R)-hydroxy(4-nitrophenyl)methyl]cyclohexanone (349628-69-9)

Guidance literature:

With L-proline; 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine tetraphenylborate; In neat (no solvent); at 0 - 3 ℃; for 120h; Temperature; stereoselective reaction;

DOI:10.1021/jo3020352

upstream raw materials:

cyclohexanone

4-nitrobenzaldehdye

trichloro<(1-cyclohexenyl)oxy>silane

cyclohex-1-enyl-trimethyl-silane