5,6,7,8-Tetrahydro-2,4(1H,3H)-quinazolinedione

Base Information

• Chemical Name: 5,6,7,8-Tetrahydro-2,4(1H,3H)-quinazolinedione
• CAS No.: 35042-48-9
• Molecular Formula: C8H10N2O2
• Molecular Weight: 166.18
• Hs Code.: 2933990090
• Mol file: 35042-48-9.mol

Synonyms:1,2,3,4,5,6,7,8-Octahydrochinazolin-2,4-dion;5,6,7,8-tetrahydro-1H,3H-quinazolin-2,4-dione;5,6,7,8-Tetrahydroquinazoline-2,4(1H,3H)-dione;5,6,7,8-tetrahydro-2,4(1H,3H)-quinazolinedione;1,2,3,4,5,6,7,8-octahydroquinazoline-2,4-dione;2,4-diketo-5,6,7,8-tetrahydroquinazoline;tetrahydroquinazolinedione;2,3,5,6,7,8-hexahydro-4(1H)-pyrimidine-2,4-dione;2,4(1H,3H)-Quinazolinedione, 5,6,7,8-tetrahydro-;1,3,5,6,7,8-Hexahydroquinazoline-2,4-dione;

Chemical Property of 5,6,7,8-Tetrahydro-2,4(1H,3H)-quinazolinedione

Chemical Property:

• Vapor Pressure: 6.3E-09mmHg at 25°C
• Melting Point: 305 °C(Solv: ethanol (64-17-5))
• Boiling Point: 455.8oC at 760 mmHg
• PKA: 10.55±0.20(Predicted)
• Flash Point: 229.5oC
• PSA: 65.72000
• Density: 1.31g/cm3
• LogP: -0.05800
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

5,6,7,8-Tetrahydroquinazoline-2,4(1H,3H)-dione ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5,6,7,8-Tetrahydro-2,4(1H,3H)-quinazolinedione

There total 23 articles about 5,6,7,8-Tetrahydro-2,4(1H,3H)-quinazolinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

ethyl 2-oxocyclohexane carboxylate (1655-07-8) + urea (57-13-6) → 2,4-Dihydroxy-5,6,7,8-tetrahydroquinazoline (35042-48-9)

Guidance literature:

With sodium methylate; In ethanol; for 48h; Reflux;

Reference yield: 91.0%

ethyl 2-oxocyclohexane carboxylate (1655-07-8) + urea (57-13-6) → 5,6,7,8-tetrahydroquinazoline-2,4(1H,3H)-dione (35042-48-9)

Guidance literature:

With sodium methylate; In ethanol; Reflux;

DOI:10.1021/acs.jmedchem.0c00774

Reference yield: 84.0%

2,4-Bis-methanesulfonyl-5,6,7,8-tetrahydro-quinazoline (179806-26-9) → 5,6,7,8-tetrahydroquinazoline-2,4(1H,3H)-dione (35042-48-9)

Guidance literature:

With sodium hydroxide; for 1h; Heating;

DOI:10.1016/0040-4020(96)00368-7

upstream raw materials:

2-sulfanylidene-1,2,3,4,5, 6,7,8-octahydroquinazolin-4-one

2-methoxy-5,6,7,8-tetrahydro-3H-quinazolin-4-one

4-Ethoxy-2,3,5,6,7,8-hexahydro-chinazolin-2-on

2-sulfhydryl-5,6,7,8-tetrahydroquinazolin-4(3H)-one

Downstream raw materials:

3-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-ethyl}-5,6,7,8-tetrahydro-1H-quinazoline-2,4-dione; hydrochloride

1-(benzyloxymethyl)-1,2,3,4,5,6,7,8-octahydroquinazoline-2,4-dione

1-(3-methoxycarbonylbenzyl)-5,6,7,8-tetrahydroquinazoline-2,4(1H,3H)-dione

1-(3-carboxybenzyl)-5,6,7,8-tetrahydroquinazoline-2,4(1H,3H)-dione