2-(Chloromethyl)-5-(4-ethylphenyl)-1,3,4-oxadiazole

Base Information

Chemical Name:2-(Chloromethyl)-5-(4-ethylphenyl)-1,3,4-oxadiazole
CAS No.:350672-18-3
Molecular Formula:C11H11ClN2O
Molecular Weight:222.67100
Hs Code.:
DSSTox Substance ID:DTXSID401223160
Mol file:350672-18-3.mol

Synonyms:2-(chloromethyl)-5-(4-ethylphenyl)-1,3,4-oxadiazole;DTXSID401223160;AKOS000123188;350672-18-3;AN-611/41104589

Suppliers and Price of 2-(Chloromethyl)-5-(4-ethylphenyl)-1,3,4-oxadiazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-(Chloromethyl)-5-(4-ethylphenyl)-1,3,4-oxadiazole

Chemical Property:

PSA：38.92000
LogP:3.03780
XLogP3:2.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:222.0559907
Heavy Atom Count:15
Complexity:195

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC1=CC=C(C=C1)C2=NN=C(O2)CCl

Technology Process of 2-(Chloromethyl)-5-(4-ethylphenyl)-1,3,4-oxadiazole

There total 2 articles about 2-(Chloromethyl)-5-(4-ethylphenyl)-1,3,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 64328-55-8
4-ethylbenzoic acid hydrazide

: 350672-18-3
2-chloromethyl-5-(4-ethyl-phenyl)-[1,3,4]oxadiazole

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran

2: POCl₃ / 3 h / Heating

With trichlorophosphate; In tetrahydrofuran;
DOI:10.1021/jf0208029

Reference yield:

: 36207-13-3
ethyl ester of para-ethylbenzoic acid

: 350672-18-3
2-chloromethyl-5-(4-ethyl-phenyl)-[1,3,4]oxadiazole

Guidance literature:: Multi-step reaction with 3 steps

1: N₂H₄*H₂O

2: tetrahydrofuran

3: POCl₃ / 3 h / Heating

With hydrazine hydrate; trichlorophosphate; In tetrahydrofuran;
DOI:10.1021/jf0208029

Reference yield: 74.0%

: 76041-71-9
3-chloro-5-(trifluoromethyl)-2-hydroxypyridine

: 350672-18-3
2-chloromethyl-5-(4-ethyl-phenyl)-[1,3,4]oxadiazole

: 2-(5-(trifluoromethyl)pyridiloxymethyl)-5-(4-ethylphenyl)-1,3,4-oxadiazole

Guidance literature:: With tetrabutylammomium bromide; potassium carbonate; In N,N-dimethyl-formamide; at 90 ℃;
DOI:10.1016/S0022-1139(02)00172-0